Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 45
- Impact of neuronal lysosomal dysfunction on RNA transport and local translation in Alzheimer’s diseaseFrom15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling a novel role for PSEN2/?-secretase in late endosome/lysosome-endoplasmic reticulum contact sites: impact on Alzheimer’s disease pathogenesisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasisFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulationFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Inter-organelle communication through membrane contact sites in oncology and neurodegenerative diseases (InterAction)From1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration.From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Lysosomal Homeostasis in Alzheimer's diseaseFrom25 Sep 2020 → 11 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
41 - 50 of 87
- Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction(2015)
Authors: Aleksandar Peric, Wim Annaert
Pages: 363 - 381 - Sequence-dependent internalisation of aggregating peptides(2015)
Authors: Rodrigo Gallardo, Frederik De Smet, Greet De Baets, Wim Annaert, Joost Schymkowitz, Frederic Rousseau
Pages: 242 - 58 - Tumor Vessel Normalization by Chloroquine Independent of Autophagy(2014)
Authors: Hannelore Maes, Anna Kuchnio, Aleksandar Peric, Stijn Moens, Kris Nys, Katrien De Bock, Annelies Quaegebeur, Sandra Schoors, Jasper Wouters, Hugo Vankelecom, et al.
Pages: 190 - 206 - MAN1B1-CDG: how stressed-out can the Golgi be?(2014)
Authors: Romain Péanne, Daisy Rymen, Nathalie Jurisch-Yaksi, Francois Foulquier, Wim Annaert, Gert Matthijs
Pages: 1105 - 1105 - Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels(2013)
Authors: Nathalie Jurisch-Yaksi, Sebastian Munck, Daphne Verleyen, Przemko Tylzanowski, Emre Yaksi, Thomy de Ravel de l'Argentière, Guy Froyen, Wim Annaert
Pages: 709 - 720 - Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer's disease(2013)
Authors: Nathalie Jurisch-Yaksi, Wim Annaert
Pages: 61 - 67 - A fast growing spectrum of biological functions of gamma-secretase in development and disease(2013)
Authors: Nathalie Jurisch-Yaksi, Wim Annaert
Pages: 2815 - 2827 - The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo(2012)
Authors: Lujia Zhou, Soraia Barao, Mathias Laga, Katrijn Bockstael, Marianne Borgers, Harry Gijsen, Wim Annaert, Diederik Moechars, Marc Mercken, Kris Gevaert, et al.
Pages: 33719 - 33719 - Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain(2012)
Authors: Carl Esselens, Rodrigo Gallardo, Bart De Strooper, Frederic Rousseau, Joost Schymkowitz, Wim Annaert
Pages: 3765 - 3778 - Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells(2012)
Authors: Katrijn Coen, Sebastian Munck, Frank Wuytack, Wim Annaert
Pages: 23 - 35
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)