Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
1 - 10 of 46
- 'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNAFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Structural and functional insights into the role of Themis:SHP-1 complexes in inflammationFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- An integrated approach to unravel eosinophil function in chronic eosinophilic disordersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Understanding the immunological basis of persistent airway obstruction in asthmaFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31From15 Jul 2020 → 30 Sep 2022Funding: IOF - technology concept exploration
- Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammationFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.From1 Nov 2019 → 28 Oct 2023Funding: FWO Strategic Basic Research Grant
- Structural and functional insights into the role of Themis1 and Themis2 in inflammation.From1 Oct 2019 → 30 Sep 2022Funding: FWO junior postdoctoral fellowship
Publications
41 - 50 of 102
- Protein crystallization promotes type 2 immunity and is reversible by antibody treatment(2019)
Authors: Emma Persson, Kenneth Verstraete, Ines Heyndrickx, Elien Gevaert, Helena Catharine Aegerter, Jean-Michel Percier, Kim Deswarte, Koen Verschueren, Ann Dansercoer, Delphine Gras, et al.
- Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle(2019)
Authors: Koen Verschueren, Clement Blanchet, Jan Felix, Dirk De Vos, Yehudi Bloch, Jozef Van Beeumen, Dmitri Svergun, Irina Gutsche, Savvas Savvides, Kenneth Verstraete
Pages: 571 - 575 - Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation(2019)
Authors: Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, et al.
- Disruption of endocytosis through chemical inhibition of clathrin heavy chain function(2019)
Authors: Wim Dejonghe, Isha Sharma, Bram Denoo, Steven De Munck, Qing Lu, Kiril Mishev, Haydar Bulut, Evelien Mylle, Riet De Rycke, Mina Vasileva, et al.
Pages: 641 - 649 - Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis(2019)
Authors: Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna-Kaisa Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, et al.
- Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa(2018)
Authors: Aleksandra Fulara, Isabel Vandenberghe, Randy J Read, Bart Devreese, Savvas Savvides
- Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors(2018)
Authors: Kiril Mishev, Qing Lu, Bram Denoo, Francois Peurois, Wim Dejonghe, Jan Hullaert, Sjef Boeren, Marine Bretou, Steven De Munck, Isha Sharma, et al.
Pages: 2573 - 2593 - Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering(2018)
Authors: Michiel Krols, Sammy Detry, Bob Asselbergh, Leonardo Almeida-Souza, Anna Kremer, Saskia Lippens, Vicky De Winter, Franz-Josef Müller, Ingo Kurth, Harvey T McMahon, et al.
Pages: 2026 - 2038 - Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha(2018)
Authors: Renée Van der Cruyssen, Eveline Verheugen, Sofie Van Gassen, Yvan Saeys, Takao Iwawaki, Yehudi Bloch, Savvas Savvides, Michael Drennan
- Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells(2018)
Authors: Stephanie Lienart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G Coulie, et al.
Pages: 952 - 956
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)