Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
31 - 40 of 46
- Molecular and structural basis of type-II secretion systems of pathogenic Gram-negative bacteriaFrom1 Oct 2012 → 14 Jun 2013Funding: BOF - Doctoral projects
- 3D Structural Platform for Chemical Excellence.From3 Jul 2012 → 31 Aug 2017Funding: Hercules - Small and Medium size research infrastructure
- Intracellular therapeutic alphabodiesFrom1 Mar 2012 → 31 Aug 2014Funding: IWT / VLAIO - indirect funding by business world
- Structural and molecular basis of the inflammatory TSLP:TSLPR:IL7-Ralpha assemblyFrom1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- The T2SS, an anti-virulence drug-target against Pseudomonas aeruginosa infectionsFrom1 Oct 2011 → 30 Jun 2016Funding: IWT personal funding - specialisation scholarships
- Structural biology of Interleukin-34, a novel cytokine ligand for colony stimulating factor 1 receptor (CSF-1R)From1 Oct 2011 → 30 Sep 2015Funding: BOF - Other initiatives, FWO fellowships
- Validation of the hematopoietic Flt3-D3 ectodomain as a novel drug target for cancer and immunostimuFrom1 Aug 2011 → 31 Jul 2012Funding: IOF - Industrial Research Fund
- The structural biology of Interleukin-34, a novel cytokine-ligand for the colony stimulating factor 1 receptor (CSF1R)From1 Oct 2010 → 30 Sep 2012Funding: BOF - Doctoral projects
- Dissection of the molecular basis of bacterial type II secretion in pathogenic bacteriaFrom1 Jan 2010 → 31 Oct 2016Funding: BOF - Concerted Research Project from 1994
- Dissection of the molecular basis of bacterial type II secretion in pathogenic bacteriaFrom1 Jan 2010 → 31 Oct 2016Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 102
- Ym1 protein crystals promote type 2 immunity(2024)
Authors: Ines Heyndrickx, Kim Deswarte, Kenneth Verstraete, Koen Verschueren, Ursula Smole, Helena Catharine Aegerter, Ann Dansercoer, Hamida Hammad, Savvas Savvides, Bart Lambrecht
- Improving de novo protein binder design with deep learning(2023)
Authors: Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, et al.
- Pore-forming proteins as drivers of membrane permeabilization in cell death pathways(2023)
Authors: Peter Vandenabeele, Geert Bultynck, Savvas Savvides
Pages: 312 - 333 - EGOC inhibits TOROID polymerization by structurally activating TORC1(2023)
Authors: Manoël Prouteau, Clélia Bourgoint, Jan Félix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
Pages: 273 - 285 - Unexpected complexity of the ammonia monooxygenase in archaea(2023)
Authors: Logan H. Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I. Ponce-Toledo, Savvas Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Pages: 588 - 599 - Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice(2023)
Authors: Karel Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Catharine Aegerter, Andy Wullaert, et al.
- Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice(2022)
Authors: Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, et al.
Pages: 1413 - 1427.e2 - The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function(2022)
Authors: Rebeca Arroyo-Hornero, Ibrahim Hamad, Beatriz Corte-Real, Katrien Staes, Bas van Der Woning, Kenneth Verstraete, Savvas Savvides
Pages: 2818 - 2821 - Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27(2022)
Authors: Katarzyna Skladanowska, Yehudi Bloch, Jamie Strand, Kerry F. White, Jing Hua, Daniel Aldridge, Martin Welin, Derek T. Logan, Arne Soete, Romain Merceron, et al.
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)