Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
1 - 10 of 46
- 'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNAFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Structural and functional insights into the role of Themis:SHP-1 complexes in inflammationFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- An integrated approach to unravel eosinophil function in chronic eosinophilic disordersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Understanding the immunological basis of persistent airway obstruction in asthmaFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31From15 Jul 2020 → 30 Sep 2022Funding: IOF - technology concept exploration
- Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammationFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.From1 Nov 2019 → 28 Oct 2023Funding: FWO Strategic Basic Research Grant
- Structural and functional insights into the role of Themis1 and Themis2 in inflammation.From1 Oct 2019 → 30 Sep 2022Funding: FWO junior postdoctoral fellowship
Publications
61 - 70 of 102
- Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF(2016)
Authors: Jan Félix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo CP van Zundert, Kris Pauwels, Katka Novanska, Randy J Read, Alexandre MJJ Bonvin, Bjorn Vergauwen, et al.
- The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)(2016)
Authors: Lijun Song, Martijn Risseeuw, Fabian Hulpia, Romain Merceron, Savvas Savvides, Hélène Munier-Lehmann
Pages: 180 - 180 - Structure and assembly mechanism of the signaling complex mediated by human CSF-1(2015)
Authors: Jan Félix, Steven De Munck, Kenneth Verstraete, Leander Meuris, Jonathan Elegheert, Savvas Savvides
Pages: 1621 - 1631 - The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence(2014)
Authors: Yurong Wen, Ester Behiels, Jan Félix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese, Savvas Savvides
Pages: 10134 - 10147 - 20 Years of leptin: insights into signaling assemblies of the leptin receptor(2014)
Authors: Lennart Zabeau, Kedar Moharana, Savvas Savvides, Jan Tavernier
Pages: T9 - T23 - MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates(2014)
Authors: Yves Dondelinger, Sylvie Montessuit, Ria Roelandt, Amanda Gonçalves, Inge Bruggeman, Kathrin Weber, Clark A Sehon, Robert W Marquis, John Bertin, Peter J Gough, et al.
Pages: 971 - 981 - Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris(2014)
Authors: Bassam Al Atalah, Dieter Vanderschaeghe, Yehudi Bloch, Paul Proost, Kirsten Plas, Savvas Savvides
Pages: 413 - 424 - Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins(2014)
Authors: Kedar Moharana, Lennart Zabeau, Philippe Ringler, Henning Stahlberg, Jan Tavernier, Savvas Savvides
Pages: 866 - 877 - Structural basis of the proinflammatory signaling complex mediated by TSLP(2014)
Authors: Kenneth Verstraete, Loes van Schie, Laurens Vyncke, Yehudi Bloch, Jan Tavernier, Ewald Pauwels, Savvas Savvides
Pages: 375 - U115 - New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa(2013)
Authors: Ruben Van der Meeren, Yurong Wen, Jan Tommassen, Bart Devreese, Savvas Savvides
Pages: 1214 - 1225
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)