Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
1 - 10 of 46
- 'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNAFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Structural and functional insights into the role of Themis:SHP-1 complexes in inflammationFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- An integrated approach to unravel eosinophil function in chronic eosinophilic disordersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Understanding the immunological basis of persistent airway obstruction in asthmaFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31From15 Jul 2020 → 30 Sep 2022Funding: IOF - technology concept exploration
- Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammationFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.From1 Nov 2019 → 28 Oct 2023Funding: FWO Strategic Basic Research Grant
- Structural and functional insights into the role of Themis1 and Themis2 in inflammation.From1 Oct 2019 → 30 Sep 2022Funding: FWO junior postdoctoral fellowship
Publications
31 - 40 of 102
- Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer(2020)
Authors: Iva Marković, Savvas Savvides
- Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis(2020)
Authors: Sandra Kozak, Yehudi Bloch, Steven De Munck, Aleksandra Mikula, Isabel Bento, Savvas Savvides, Rob Meijers
Pages: 1244 - 1255 - Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis(2020)
Authors: Elien Gevaert, Tim Delemarre, Joyceline De Volder, Nan Zhang, Gabriële Holtappels, Natalie De Ruyck, Emma Persson, Ines Heyndrickx, Kenneth Verstraete, Helena Catharine Aegerter, et al.
Pages: 427 - 430 - Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)(2020)
Authors: Jan Félix, Steven De Munck, Kenneth Verstraete, Leander Meuris, Jonathan Elegheert, Savvas Savvides
- Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33(2020)
Authors: Andrea Renate Teufelberger, Sharon Van Nevel, Paco Hulpiau, Maria Nordengrün, Savvas Savvides, Sarah De Graeve, Srinivas Akula, Gabriële Holtappels, Natalie De Ruyck, Wim Declercq, et al.
- DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance(2020)
Authors: Flora D'Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, V Berrens, Rebecca, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, et al.
- Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms(2019)
Authors: Benjamin H Durham, Estibaliz Lopez Rodrigo, Jennifer Picarsic, David Abramson, Veronica Rotemberg, Steven De Munck, Erwin Pannecoucke, Sydney X Lu, Alessandro Pastore, Akihide Yoshimi, et al.
Pages: 1839 - 1842 - Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis : a molecular insight(2019)
Authors: Cuong Thach Nguyen, Yehudi Bloch, Savvas Savvides, Iannis E Adamopoulos
Pages: 15 - 22 - Revisiting the combinatorial potential of cytokine subunits in the IL-12 family(2019)
Authors: Sammy Detry, Marnik Vuylsteke, Savvas Savvides, Yehudi Bloch
Pages: 240 - 248 - IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation(2019)
Authors: Aurora Holgado Muñoz, Harald Braun, Elien Van Nuffel, Sammy Detry, Kim Deswarte, Karl Vergote, Griet Baudelet, Jurgen Haustraete, Savvas Savvides, Inna Afonina, et al.
Pages: 204 - 215
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)