Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
21 - 30 of 46
- The molecular and structural basis of pro- and anti-inflammatory signalling assemblies mediated by IL-27 and IL-35. From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Unraveling the structural and mechanistic principles of IL-35 signaling complexes pivotal to inflammation and auto-immune diseasesFrom1 Jan 2015 → 31 Dec 2018Funding: IWT personal funding - strategic basic research grants, IWT personal funding - specialisation scholarships
- Unravelling the pharmaceutical potential of receptor heterodimers for therapeutic intervention in CNS disorders.From1 Jan 2015 → 31 Dec 2017Funding: SBO (Strategic basic research)
- Structural and biophysical characterization of extracellular assemblies of the anaplastic lymphoma kinase receptorFrom1 Jan 2015 → 31 Dec 2018Funding: IWT personal funding - strategic basic research grants, IWT personal funding - specialisation scholarships
- Structural and molecular basis of proinflammatory assemblies mediated by thymic stromal lymphopoietin (TSLP).From1 Jan 2014 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Molecular and structural study of standard and pathological FLT3 receptor activationFrom1 Jan 2014 → 31 Dec 2017Funding: IWT personal funding - specialisation scholarships
- Structural and molecular basis for the cooperative assembly of the pro-inflammatory TSLP:TSLPR:IL- 7Ralpha signaling complex.From1 Oct 2013 → 30 Sep 2019Funding: FWO fellowships, BOF - Other initiatives
- Molecular and structural basis of type-II secretion systems of pathogenic Gram-negative bacteria.From1 Oct 2013 → 30 Sep 2018Funding: FWO fellowships, BOF - Other initiatives
- The molecular and structural basis of GM-CSF and IL-2 by viral GIF to achieve immunomodulation.From1 Jan 2013 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Structural insights into the assembly of the inflammatory IL-23 signaling complexesFrom1 Jan 2013 → 31 Dec 2016Funding: IWT personal funding - specialisation scholarships
Publications
1 - 10 of 102
- Ym1 protein crystals promote type 2 immunity(2024)
Authors: Ines Heyndrickx, Kim Deswarte, Kenneth Verstraete, Koen Verschueren, Ursula Smole, Helena Catharine Aegerter, Ann Dansercoer, Hamida Hammad, Savvas Savvides, Bart Lambrecht
- Improving de novo protein binder design with deep learning(2023)
Authors: Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, et al.
- Pore-forming proteins as drivers of membrane permeabilization in cell death pathways(2023)
Authors: Peter Vandenabeele, Geert Bultynck, Savvas Savvides
Pages: 312 - 333 - EGOC inhibits TOROID polymerization by structurally activating TORC1(2023)
Authors: Manoël Prouteau, Clélia Bourgoint, Jan Félix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
Pages: 273 - 285 - Unexpected complexity of the ammonia monooxygenase in archaea(2023)
Authors: Logan H. Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I. Ponce-Toledo, Savvas Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Pages: 588 - 599 - Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice(2023)
Authors: Karel Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Catharine Aegerter, Andy Wullaert, et al.
- Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice(2022)
Authors: Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, et al.
Pages: 1413 - 1427.e2 - The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function(2022)
Authors: Rebeca Arroyo-Hornero, Ibrahim Hamad, Beatriz Corte-Real, Katrien Staes, Bas van Der Woning, Kenneth Verstraete, Savvas Savvides
Pages: 2818 - 2821 - Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27(2022)
Authors: Katarzyna Skladanowska, Yehudi Bloch, Jamie Strand, Kerry F. White, Jing Hua, Daniel Aldridge, Martin Welin, Derek T. Logan, Arne Soete, Romain Merceron, et al.
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)