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Researcher
Erik De Clercq
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
1 - 10 of 564
- Design and synthesis of Fsp3-enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs.(2024)
Authors: Erik De Clercq
Pages: e14510 - Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.(2024)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 1257 - 1282 - Selected Milestones in Antiviral Drug Development.(2024)
Authors: Erik De Clercq
Pages: 169 - In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 16303 - 16329 - Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 4906 - 4917 - 5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I(2023)
Authors: Christophe Pannecouque, Erik De Clercq
- Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Patents
1 - 7 of 7
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- VIRAL INHIBITORS (Inventor)
- VIRAL INHIBITORS (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)