Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
31 - 40 of 163
- Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks(2017)
Authors: Nicola Piens, Kristof Van Hecke, Dieter Vogt, Matthias D'hooghe
Pages: 4816 - 4821 - Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin-binding proteins of resistant bacteria(2017)
Authors: Lena Decuyper, Sari Deketelaere, Marko Jukic, Izidor Sosic, Eric Sauvage, Paulette Charlier, Bernard Joris, Stanislav Gobec, Matthias D'hooghe
Number of pages: 1 - Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines(2017)
Authors: Esma Birsen Boydas, Saron Catak, Kristof Van Hecke, Matthias D'hooghe
Pages: 10092 - 10109 - LiAlH4-induced thia-aza-Payne rearrangement of functionalized 2-(thiocyanatomethyl)aziridines into 2-(aminomethyl)thiiranes as an entry to 5-(chloromethyl)thiazolidin-2-ones(2017)
Authors: Kristof Van Hecke, Matthias D'hooghe
Pages: 3229 - 3233 - Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach(2017)
Authors: Nicola Piens, Hannelore Goossens, Dietmar Hertsen, Sari Deketelaere, Lieselotte Crul, Lotte Demeurisse, Jelle De Moor, Elias Van Den Broeck, Karen Mollet, Kristof Van Hecke, et al.
Pages: 18002 - 18009 - Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors(2016)
Authors: Rob De Vreese, Yves Depetter, Tom Verhaeghe, Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch, Matthias D'hooghe
Pages: 2537 - 2549 - Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-U+03B2-lactams(2016)
Authors: Hang Dao Thi, Barbara Danneels, Kristof Van Hecke, Tuyen VanU+2005Nguyen, Matthias D'hooghe
Pages: 1480 - 1491 - Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones(2016)
Authors: Lena Decuyper, Nicola Piens, Saskia Vander Meeren, Jeroen Bomon, Bert De Schrijver, Karen Mollet, Karel De Winter, Matthias D'hooghe
Number of pages: 1 - Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity(2016)
Authors: Tom Verhaeghe, Karel De Winter, Magali Berland, Rob De Vreese, Matthias D'hooghe, Bernard Offmann
Pages: 3687 - 3689 - Synthesis of novel curcuminoids accommodating a central U+03B2-enaminone motif and their impact on cell growth and oxidative stress(2016)
Authors: Rob De Vreese, Charlotte Grootaert, Sander D'hoore, Sam Van Damme, Maarten Van Bogaert, Matthias D'hooghe
Pages: 727 - 736
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)