Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
21 - 30 of 31
- Synthesis and eva luation o f new inhibitors of penicillin-binding proteins from resistant bacteria en route to new antibacterial agentsFrom1 Oct 2014 → 1 Oct 2015Funding: BOF - Doctoral projects
- Design and development of new selective HDAC6 inhibitors with applications in cancer therapyFrom1 Oct 2014 → 14 Oct 2018Funding: BOF - Doctoral projects
- Opportunity to develop novel HDAC6 inhibitors for therapeutic useFrom15 Aug 2014 → 15 Aug 2017Funding: IOF - Industrial Research Fund
- Generation and application of 2-oxoazetidin-4-yl anions for the construction of new, biologically relevant C-, N- and spiro-fused beta-lactamsFrom1 Aug 2014 → 15 Oct 2018Funding: BOF - Doctoral projects
- Stereoselective synthesis of β-lactams and their use in multicomponent reactionsFrom1 Oct 2013 → 30 Sep 2017Funding: BOF - Other initiatives
- Regio- and stereoselective ring expansions of 2-(2-cyanoethyl)aziridines toward functionalized pyrrolidines and piperidinesFrom1 Oct 2013 → 25 Dec 2017Funding: BOF - Doctoral projects
- Catalytic carbonylation of aziridines to novel beta-lactams as versatile building blocks in heterocyclic chemistryFrom1 Mar 2013 → 31 Dec 2017Funding: BOF - Doctoral projects
- Study of 2-substituted 2-(bromomethyl)aziridines as flexible synthons in heterocyclic chemistryFrom1 Dec 2011 → 30 Nov 2012Funding: BOF - Doctoral projects
- Catalytic synthesis and ring opening of aziridines – novel protocols for the preparation of valuable nitrogen-containing target compoundsFrom1 Oct 2010 → 30 Sep 2020Funding: BOF - Research professorship, BOF - ZAP BOF mandates
- New entries to functionalized beta-lactams as versatile building blocks in heterocyclic chemistryFrom1 Jan 2010 → 31 Dec 2012Funding: FWO research grant KAN
Publications
1 - 10 of 163
- High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase(2024)
Authors: Jorick Franceus, Manon Steynen, Yentl Allaert, Kato Bredael, Matthias D'hooghe, Tom Desmet
- Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks(2023)
Authors: Sari Deketelaere, Gurkirat Kaur, Nicola Piens, Daan Deturck, Robin Depestel, Kristof Van Hecke, Christian Stevens, Vipan Kumar, Matthias D'hooghe
Pages: 423 - 430 - The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs(2023)
Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Pages: 7698 - 7729 - Synthesis of the 1,5-benzothiazepane scaffold : established methods and new developments(2023)
Authors: Ulrike Ronse, Katarina Magdalenic, Matthias D'hooghe
- Engineering Comamonas testosteroni for the production of 2-pyrone-4,6-dicarboxylic acid as a promising building block(2023)
Authors: Tom Delmulle, Stijn Bovijn, Sari Deketelaere, Martijn Castelein, Tom Erauw, Matthias D'hooghe, Wim Soetaert
- Covalent organic framework supported palladium catalysts(2022)
Authors: Hadi Salemi, Maarten Debruyne, Pascal Van Der Voort, Matthias D'hooghe, Christian Stevens
Pages: 20707 - 20729 - Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation(2022)
Authors: Freya Baele, Jorick Franceus, Matthias D'hooghe
Pages: 6239 - 6242 - The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - Unexpected formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during attempted Staudinger 2,2‐Dichloro‐β‐lactam synthesis(2021)
Authors: Sari Deketelaere, Elias Van Den Broeck, Lore Cools, Daan Deturck, Hannes Naeyaert, Kristof Van Hecke, Christian Stevens, Matthias D'hooghe
Pages: 5823 - 5830 - Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3(2021)
Authors: Jorick Franceus, Jolien Lormans, Lore Cools, Matthias D'hooghe
Pages: 6225 - 6233
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)