Researcher
Rob De Vreese
- Disciplines:Natural products chemistry
Affiliations
- Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Aug 2011 → 24 Sep 2017
Publications
1 - 10 of 19
- Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models(2019)
Authors: Yves Depetter, Rob De Vreese, Sophie Goethals, Elien Vandoorn, Alien Laevens, Jonas Steenbrugge, Pascal de Tullio, Marc Bracke, Matthias D'hooghe
Pages: 735 - 747 - Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition(2018)
Authors: Yves Depetter, Flore Vanden Bussche, Rob De Vreese, Jorick Franceus, Matthias D'hooghe
Pages: 1011 - 1016 - Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold(2017)
Authors: Rob De Vreese, Lisa Galle, Yves Depetter, Jorick Franceus, Kristof Van Hecke, Veronick Benoy, Ludo VanU+2005DenU+2005Bosch, Matthias D'hooghe
Pages: 128 - 136 - Synthesis of thiaheterocyclic benzohydroxamic acids and evaluation of their HDAC6 inhibitory activity(2017)
Authors: Rob De Vreese
- Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors(2016)
Authors: Rob De Vreese, Yves Depetter, Tom Verhaeghe, Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch, Matthias D'hooghe
Pages: 2537 - 2549 - Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity(2016)
Authors: Tom Verhaeghe, Karel De Winter, Magali Berland, Rob De Vreese, Matthias D'hooghe, Bernard Offmann
Pages: 3687 - 3689 - Synthesis of novel curcuminoids accommodating a central U+03B2-enaminone motif and their impact on cell growth and oxidative stress(2016)
Authors: Rob De Vreese, Charlotte Grootaert, Sander D'hoore, Sam Van Damme, Maarten Van Bogaert, Matthias D'hooghe
Pages: 727 - 736 - Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl U+03B2-enaminone curcuminoids(2016)
Authors: Rob De Vreese, Lore Vannecke, Charlotte Grootaert, Matthias D'hooghe
Pages: 5650 - 5656 - Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors(2015)
Authors: Rob De Vreese, Nicholas Van Steen, Tom Verhaeghe, Nadia Bougarne, Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch, Matthias D'hooghe
Pages: 9868 - 9871 - Synthesis of novel thymine-U+03B2-lactam hybrids and evaluation of their anti-tumor activity(2015)
Authors: Nicola Piens, Rob De Vreese, Kristof Van Hecke, Jan Balzarini, Norbert De Kimpe, Matthias D'hooghe
Number of pages: 1
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)