Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
11 - 20 of 163
- Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity(2020)
Authors: Tim Van de Walle, Marina Briand, Ana Mitrovic, Izidor Sosic, Stanislav Gobec, Janko Kos, Leentje Persoons, Dirk Daelemans, Steven De Jonghe, Zorica Ubiparip, et al.
Pages: 2477 - 2490 - Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines(2020)
Authors: Lena Decuyper, Marko Jukic, Izidor Sosic, Ana Maria Amoroso, Olivier Verlaine, Bernard Joris, Stanislav Gobec, Matthias D'hooghe
Pages: 51 - 55 - Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties(2020)
Authors: Aleksandra Minić, Tim Van de Walle, Kristof Van Hecke, Jill Combrinck, Peter J. Smith, Kelly Chibale, Matthias D'hooghe
- Expedient synthesis of lupulones and their derivatization to 2,8-7H-dihydrochromen-7-ones(2020)
Authors: Lena Decuyper, Gurkirat Kaur, Charlotte Versyck, Eline Blondeel, Yves Depetter, Kristof Van Hecke, Matthias D'hooghe
Pages: 442 - 444 - Electrophilic bromination in flow : a safe and sustainable alternative to the use of molecular bromine in batch(2019)
Authors: Reinout Van Kerrebroeck, Pieter Naert, Thomas Heugebaert, Matthias D'hooghe, Christian Stevens
- Synthesis of 1,4U+2010thiazepaneU+2010based curcuminoids with promising anticancer activity(2019)
Authors: Tim Van de Walle, Kristof Van Hecke, Charlotte Grootaert, Matthias D'hooghe
Pages: 12583 - 12600 - Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models(2019)
Authors: Yves Depetter, Rob De Vreese, Sophie Goethals, Elien Vandoorn, Alien Laevens, Jonas Steenbrugge, Pascal de Tullio, Marc Bracke, Matthias D'hooghe
Pages: 735 - 747 - Synthesis of nonU+2010symmetrical nitrogenU+2010containing curcuminoids in the pursuit of new anticancer candidates(2019)
Authors: Tim Van de Walle, Charlotte Grootaert, Kristof Van Hecke, Nathalie Catry, Matthias D'hooghe
Pages: 236 - 247 - Synthesis of indolineU+2010based benzhydroxamic acids as potential HDAC6 inhibitors(2019)
Authors: Yves Depetter, Jorick Franceus, Damijan Knez, Stanislav Gobec, Matthias D'hooghe
Pages: 12308 - 12312 - Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives(2019)
Authors: Tim Van de Walle, Charlotte Grootaert, Steven De Jonghe, Leentje Persoons, Dirk Daelemans, Kristof Van Hecke, Matthias D'hooghe
Pages: 2045 - 2051
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)