Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
11 - 20 of 31
- Sustainable chemistry for the synthesis of fine chemicalsFrom1 Jan 2020 → TodayFunding: FWO scientific research network
- Aziridine-based CO2 capture – a new approach toward the synthesis of fluorinated oxazolidinonesFrom1 Nov 2019 → 25 Apr 2021Funding: FWO fellowships
- Aziridine-based CO2 capture – a new approach toward the synthesis of fluorinated oxazolidinones.From1 Oct 2019 → 1 Nov 2019Funding: BOF - doctoral mandates
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Jan 2019 → 31 Mar 2023Funding: FWO Strategic Basic Research Grant
- Synthesis and biological assessment of novel β-lactamase inhibitors in the framework of tuberculosis therapy in IndiaFrom1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Exploration of HDAC6 inhibitors as anti-inflammatory agents – linking HDAC6 chemistry with inflammation biologyFrom1 Oct 2017 → 30 Sep 2021Funding: BOF - Doctoral projects
- Explorations in quinoline chemistry – towards the development of novel piperidine-quinoline hybrids with antimalarial activity and nitroxoline analogs with anti-tumor activityFrom1 Oct 2016 → 30 Sep 2020Funding: BOF - Doctoral projects
- Employment of functionalized azetin-2-ones for the synthesis of biologically relevant C-, N- and spiro-fused beta-lactams.From1 Jan 2016 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Synthesis and biological evaluation of new beta-lactam containing inhibitors of penicillin-binding proteins from resistant bacteria.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- Safe and efficient dehydration of organic solvents for synthesis purposes by means of a ‘Solvent Purification System’From1 Jun 2015 → 31 May 2017Funding: BOF - Other initiatives
Publications
1 - 10 of 163
- High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase(2024)
Authors: Jorick Franceus, Manon Steynen, Yentl Allaert, Kato Bredael, Matthias D'hooghe, Tom Desmet
- Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks(2023)
Authors: Sari Deketelaere, Gurkirat Kaur, Nicola Piens, Daan Deturck, Robin Depestel, Kristof Van Hecke, Christian Stevens, Vipan Kumar, Matthias D'hooghe
Pages: 423 - 430 - The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs(2023)
Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Pages: 7698 - 7729 - Synthesis of the 1,5-benzothiazepane scaffold : established methods and new developments(2023)
Authors: Ulrike Ronse, Katarina Magdalenic, Matthias D'hooghe
- Engineering Comamonas testosteroni for the production of 2-pyrone-4,6-dicarboxylic acid as a promising building block(2023)
Authors: Tom Delmulle, Stijn Bovijn, Sari Deketelaere, Martijn Castelein, Tom Erauw, Matthias D'hooghe, Wim Soetaert
- Covalent organic framework supported palladium catalysts(2022)
Authors: Hadi Salemi, Maarten Debruyne, Pascal Van Der Voort, Matthias D'hooghe, Christian Stevens
Pages: 20707 - 20729 - Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation(2022)
Authors: Freya Baele, Jorick Franceus, Matthias D'hooghe
Pages: 6239 - 6242 - The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - Unexpected formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during attempted Staudinger 2,2‐Dichloro‐β‐lactam synthesis(2021)
Authors: Sari Deketelaere, Elias Van Den Broeck, Lore Cools, Daan Deturck, Hannes Naeyaert, Kristof Van Hecke, Christian Stevens, Matthias D'hooghe
Pages: 5823 - 5830 - Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3(2021)
Authors: Jorick Franceus, Jolien Lormans, Lore Cools, Matthias D'hooghe
Pages: 6225 - 6233
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)