Researcher
Matthias D'hooghe
- Disciplines:Organic chemical synthesis, Medicinal chemistry
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → Today - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From1 Sep 2001 → 31 Dec 2017
Projects
1 - 10 of 31
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.From1 Apr 2023 → 30 Apr 2023Funding: BOF - doctoral mandates
- Purchase of LC-MS equipment for the analysis of organic compounds, reaction mixtures and natural extractsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellsFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- Design and development of carbapenem- and cephalosporin-based monocyclic beta-lactam derivatives to address antibiotic-insensitive penicillin-binding proteinsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Curcumin-derived functionalized thiazepanes to selectively target colon cancer cellFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Purchase of GC-MS equipment for the analysis of volatile organic compounds.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- From thiazepane curcuminoid hit structures to new anticancer lead compoundsFrom1 Oct 2020 → TodayFunding: BOF - projects
Publications
41 - 50 of 163
- A nitrilase-mediated entry to 4-carboxymethyl-U+03B2-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones(2016)
Authors: Lena Decuyper, Nicola Piens, Jeroen Bomon, Bert De Schrijver, Karen Mollet, Karel De Winter, Matthias D'hooghe
Pages: 54573 - 54579 - Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized U+03B3-lactams and U+03B2-lactams(2016)
Authors: Nicola Piens, Lena Decuyper, Saskia Vander Meeren, Jeroen Bomon, Bert De Schrijver, Karen Mollet, Karel De Winter, Matthias D'hooghe
Number of pages: 1 - Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic U+03B2-lactams(2016)
Authors: Nicola Piens, Sven De Craene, Jorick Franceus, Karen Mollet, Kristof Van Hecke, Matthias D'hooghe
Pages: 11279 - 11288 - Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-U+03B2-lactam building blocks(2016)
Authors: Hang Dao Thi, Lena Decuyper, Karen Mollet, Sara Kenis, Norbert De Kimpe, Tuyen Van Nguyen, Matthias D'hooghe
Pages: 1100 - 1105 - Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl U+03B2-enaminone curcuminoids(2016)
Authors: Rob De Vreese, Lore Vannecke, Charlotte Grootaert, Matthias D'hooghe
Pages: 5650 - 5656 - Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic U+03B2-lactams(2016)
Authors: Nicola Piens, Sven De Craene, Karen Mollet, Kristof Van Hecke, Matthias D'hooghe
Number of pages: 1 - Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs(2015)
Authors: Anh Dang Thi Tuyet, Ha Vu Thi Thu, Thi Phuong Hoang, Ha Nguyen Thanh, Pham The Chinh, Vu Duc Cuong, Yves Depetter, Van Nguyen Tuyen, Matthias D'hooghe
Pages: 3355 - 3358 - Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors(2015)
Authors: Rob De Vreese, Nicholas Van Steen, Tom Verhaeghe, Nadia Bougarne, Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch, Matthias D'hooghe
Pages: 9868 - 9871 - Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones(2015)
Authors: Tuyet Anh Dang Thi, Yves Depetter, Karen Mollet, Hoang Thi Phuong, Doan Vu Ngoc, Chinh Pham The, Ha Thanh Nguyen, Thu Ha Nguyen Thi, Hung Huy Nguyen, Matthias D'hooghe, et al.
Pages: 2422 - 2425 - Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards U+03B3-lactams and U+03B3-lactones(2015)
Authors: Karen Mollet, Lena Decuyper, Saskia Vander Meeren, Nicola Piens, Karel De Winter, Matthias D'hooghe
Pages: 2716 - 2725
Patents
1 - 2 of 2
- Selective HDAC6 inhibitors and uses thereof (Inventor)
- HDAC6 Inhibitors and uses thereof (Inventor)