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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
1 - 10 of 31
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- ORDECA – ORganoid Drug screening for Endometrial CAncerIdentifying novel drugs and biomarkers for treating endometrial cancer using a high-throughput patient-derived organoid drug discovery and screening platformFrom1 Oct 2023 → TodayFunding: IOF - technology validation in lab
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Investigation of the SARS-CoV-2.From1 Sep 2020 → 31 Aug 2022Funding: Foreign Nonprofit organisations and equivalents
Publications
101 - 110 of 123
- Interplay between HIV entry and transportin-SR2 dependency(2011)
Authors: Wannes Thys, Stéphanie De Houwer, Jonas Demeulemeester, Oliver Taltynov, Renée Vancraenenbroeck, Jan De Rijck, Rik Gijsbers, Frauke Christ, Zeger Debyser
Pages: 7 - A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors(2011)
Authors: Frauke Christ, Zeger Debyser
Pages: 343 - 352 - Assays for evaluation of HIV-1 integrase enzymatic activity, DNA binding, and cofactor interaction(2011)
Authors: Frauke Christ, Katrien Busschots, Jelle Hendrix, Melissa McNeely, Yves Engelborghs, Zeger Debyser, Nouri Neamati
Pages: 151 - 163 - 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4(2010)
Authors: Myriam Witvrouw, Frauke Christ, Zeger Debyser
Pages: 535 - 546 - Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor(2010)
Authors: Frauke Christ, Zeger Debyser
Pages: 7515 - 7521 - New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action(2010)
Authors: Frauke Christ, Zeger Debyser
Pages: 5510 - 5518 - Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication(2010)
Authors: Frauke Christ, Arnout Voet, Belete Ayele Desimmie, Sergei Strelkov, Marc De Maeyer, Patrick Chaltin, Zeger Debyser
Pages: 442 - 448 - On the cell biology of HIV integration from basic research to development of novel antiviral drugs(2010)
Authors: Zeger Debyser, Frauke Christ
Pages: 219 - 237 - Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents(2009)
Authors: Frauke Christ
Pages: 1420 - 1424 - In search of second generation HIV integrase inhibitors; targeting integration beyond strand transfer(2009)
Authors: Arnout Voet, Marc De Maeyer, Zeger Debyser, Frauke Christ
Pages: 1259 - 1274
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)