Researcher
Jan De Rijck
- Disciplines:Microbiology, Systems biology, Laboratory medicine, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → 15 Oct 2017 - Faculty of Medicine (Faculty)
Member
From1 Oct 2001 → 30 Sep 2005
Projects
1 - 10 of 13
- Development of an LEDGF/p75 based strategy for the treatment of MLL-rearranged leukemia.From1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Single virus imaging of early steps of HIV replicationFrom1 Oct 2017 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
- Development of a new therapeutic strategy for the treatment of MLL-rearranged acute leukemiaFrom1 Jan 2017 → 16 Nov 2022Funding: FWO Strategic Basic Research Grant
- Safer retroviral vectors for gene therapy: design, evaluation and validationFrom1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Engineering, evaluation and validation of safer vectors for gene therapyFrom1 Jan 2015 → 30 Sep 2019Funding: FWO Strategic Basic Research Grant
- The interactome of retroviral nuclear import and integration.From1 Oct 2013 → 30 Sep 2017Funding: BOF - Concerted Research Project from 1994
- LEDGF/p75 chromatin tethering as a target to treat Jpo2 and MLL dependent malignanciesFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- A novel therapeutic approach for acute leukemia by targeting LEDGF/p75.From1 Jan 2012 → 31 Dec 2014Funding: FWO research grant KAN
- Validation of novel Cellular cofactors of retroviral nuclear import and integration.From13 Sep 2011 → 12 May 2016Funding: FWO fellowships
- A novel therapeutic approach for acute leukemia by targeting LEDGF/p75.From1 Aug 2011 → 30 Sep 2015Funding: FWO fellowships
Publications
1 - 10 of 41
- Retargeting retroviral integration: next-generation MLV vectors for safer gene therapy(2019)
Authors: Dominique Van Looveren, Rik Gijsbers, Jan De Rijck
- Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation(2018)
Authors: Jan De Rijck, Jonas Demeulemeester, Siska Van Belle, Frauke Christ, Zeger Debyser
Pages: E7053 - E7062 - LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis(2017)
Authors: Sara Elashkar, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Nancy Boeckx, Zeger Debyser, Jan De Rijck
Pages: 95 - 107 - Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy(2017)
Authors: Dominique Van Looveren, Lenard Vranckx, Jonas Demeulemeester, Jan De Rijck, Zeger Debyser, Rik Gijsbers
Pages: 231 - 245 - Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets(2017)
Authors: Jolien Blokken, Jan De Rijck, Frauke Christ, Zeger Debyser
Pages: 25 - 31 - Lessons learned: HIV points the way towards precision treatment of mixed-lineage leukemia(2016)
Authors: Caroline Weydert, Frauke Christ, Jan De Rijck, Zeger Debyser
Pages: 660 - 671 - Targeting virus-host interactions of HIV replication(2016)
Authors: Caroline Weydert, Jan De Rijck, Frauke Christ, Zeger Debyser
Pages: 1167 - 1190 - Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection(2015)
Authors: Jonas Demeulemeester, Jan De Rijck, Rik Gijsbers, Zeger Debyser
Pages: 1202 - 14 - HIV-1 IN/Pol recruits LEDGF/p75 into viral particles(2015)
Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Jan De Rijck, Rik Gijsbers, Frauke Christ, Zeger Debyser
- HIV-1 IN/Pol recruits LEDGF/p75 into viral particles(2015)
Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Igor Paron, Jan De Rijck, Jan Mast, Norbert Bannert, et al.
Pages: 1 - 15
Patents
1 - 1 of 1