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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
1 - 10 of 31
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- ORDECA – ORganoid Drug screening for Endometrial CAncerIdentifying novel drugs and biomarkers for treating endometrial cancer using a high-throughput patient-derived organoid drug discovery and screening platformFrom1 Oct 2023 → TodayFunding: IOF - technology validation in lab
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Investigation of the SARS-CoV-2.From1 Sep 2020 → 31 Aug 2022Funding: Foreign Nonprofit organisations and equivalents
Publications
111 - 120 of 123
- Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75(2009)
Authors: Frauke Christ, Zeger Debyser
Pages: 1311 - 1316 - Exploration of novel hiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors(2009)
Authors: Frauke Christ, Myriam Witvrouw, Zeger Debyser
Pages: 3615 - 3618 - Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ(2009)
Authors: Frauke Christ, Jelle Hendrix, Zeger Debyser, Rik Gijsbers, Jan De Rijck
Pages: 11467 - 11477 - Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives(2009)
Authors: Frauke Christ, Zeger Debyser, Arnout Voet
Pages: 71 - +Number of pages: 33 - LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy(2009)
Authors: Wannes Thys, Katrien Busschots, Melissa McNeely, Arnout Voet, Frauke Christ, Zeger Debyser
Pages: 171 - 188 - In search of small molecules blocking interactions between HIV proteins and intracellular cofactors(2009)
Authors: Jan De Rijck, Frauke Christ, Zeger Debyser
Pages: 21 - 31 - Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions(2009)
Authors: Frauke Christ, Myriam Witvrouw, Zeger Debyser
Pages: 569 - 573 - Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain(2008)
Authors: Myriam Witvrouw, Frauke Christ, Zeger Debyser
Pages: 7717 - 7730 - Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors(2008)
Authors: Myriam Witvrouw, Frauke Christ, Zeger Debyser
Pages: 5125 - 5129 - Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors(2008)
Authors: Anneleen Hombrouck, Frauke Christ, Zeger Debyser, Myriam Witvrouw
Pages: 2861 - 2869
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)