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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
11 - 20 of 31
- Strategies against persistent HIV-1 reservoirs(SAPHIR)From1 Jan 2020 → 31 Dec 2023Funding: FWO Strategic Basic Research (SBO)
- Targeting the chromatin-reader function of LEDGF/p75 for the treatment of Mixed-Lineage-Leukemia (TReaT-MLL)From1 Oct 2018 → 30 Sep 2020Funding: IOF - Industrial Research Fund
- Development of an LEDGF/p75 based strategy for the treatment of MLL-rearranged leukemia.From1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Single virus imaging of early steps of HIV replicationFrom1 Oct 2017 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
- Development of a new therapeutic strategy for the treatment of MLL-rearranged acute leukemiaFrom1 Jan 2017 → 16 Nov 2022Funding: FWO Strategic Basic Research Grant
- High throughput analysis of biomolecular interactionsFrom1 May 2016 → 30 Apr 2020Funding: FWO Medium Size Research Infrastructure
- Research on the mechanism of action of a new class antivirals, the LEDGINs, with a potential application for the functional cure of HIV infectionFrom8 Jan 2016 → 16 Jan 2020Funding: FWO Strategic Basic Research Grant
- Single virus analysis of inhibitors of early HIV replication using fluorescence-based methods.From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Organoid platform for the development of innovative treatments for Cystic FibrosisFrom1 Oct 2015 → 30 Sep 2017Funding: IOF - Industrial Research Fund
- Development of integrated single virus technology to study the early replication steps of HIVFrom1 Jan 2015 → 3 Oct 2019Funding: FWO fellowships
Publications
1 - 10 of 123
- Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection(2023)
Authors: Eline Pellaers, Anayat Bhat, Frauke Christ, Zeger Debyser
- Development of a new therapeutic strategy for the treatment of MLL-rearranged acute leukemia(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids(2022)
Authors: Marjolein Ensinck, Senne Cuyx, Lieven Dupont, Frauke Christ, Zeger Debyser, François Vermeulen, Marianne Carlon
- LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators(2022)
Authors: Siska Van Belle, Tine Brouns, Marianne Carlon, Frauke Christ, Zeger Debyser
Pages: 133 - 140 - CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Rik Gijsbers, Frauke Christ, Zeger Debyser
- GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture(2021)
Authors: Anne Bruggemans, Frauke Christ, Zeger Debyser
- Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Frauke Christ, Zeger Debyser
- Towards a functional cure of HIV-1: insight in the chromatin landscape of the provirus(2021)
Authors: Julie Janssens, Anne Bruggemans, Frauke Christ, Zeger Debyser
- Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival(2021)
Authors: Siska Van Belle, Frauke Christ, Zeger Debyser
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)