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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
21 - 30 of 31
- Role of transportin-SR2 in HIV-mediated nuclear import.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- The interactome of retroviral nuclear import and integration.From1 Oct 2013 → 30 Sep 2017Funding: BOF - Concerted Research Project from 1994
- HIV nuclear import and chromatin reading as novel drug targetsFrom1 Sep 2013 → 30 Nov 2018Funding: BOF - Doctoral projects
- Structural studies of transportin SR2, the nuclear import factor of HIV-1.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- LEDGINs and the molecular mechanism of LEDGF/p75 mediated HIV integration.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Molecular mechanism of Transportin-SR2 mediated nuclear import of HIV.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project (including WEAVE projects)
- On the cell biology of retroviral integration.From1 Oct 2009 → 30 Sep 2013Funding: BOF - Concerted Research Project from 1994
- Nuclear import of HIV as a target for new antiviral therapyFrom1 Oct 2009 → 29 Jan 2014Funding: IWT personal funding - strategic basic research grants
- Development of inhibitors of integrase-LEDGF/P75 interaction.From23 Jul 2009 → 30 Jun 2011Funding: Other international institutions, not mentioned elsewhere
- Novel HIV inhibitors targeting the interaction between integrase and LEDGF/p75From1 Sep 2008 → 12 Dec 2012Funding: BOF - Doctoral projects
Publications
1 - 10 of 123
- Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection(2023)
Authors: Eline Pellaers, Anayat Bhat, Frauke Christ, Zeger Debyser
- Development of a new therapeutic strategy for the treatment of MLL-rearranged acute leukemia(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids(2022)
Authors: Marjolein Ensinck, Senne Cuyx, Lieven Dupont, Frauke Christ, Zeger Debyser, François Vermeulen, Marianne Carlon
- LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators(2022)
Authors: Siska Van Belle, Tine Brouns, Marianne Carlon, Frauke Christ, Zeger Debyser
Pages: 133 - 140 - CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Rik Gijsbers, Frauke Christ, Zeger Debyser
- GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture(2021)
Authors: Anne Bruggemans, Frauke Christ, Zeger Debyser
- Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Frauke Christ, Zeger Debyser
- Towards a functional cure of HIV-1: insight in the chromatin landscape of the provirus(2021)
Authors: Julie Janssens, Anne Bruggemans, Frauke Christ, Zeger Debyser
- Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival(2021)
Authors: Siska Van Belle, Frauke Christ, Zeger Debyser
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)