Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 80
- MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's diseaseFrom16 May 2024 → TodayFunding: Foundations, funds and other with scientific goal
- Spatial Proteomics to Investigate the Cellular Phase of Alzheimer’s DiseaseFrom13 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel chimeric model investigating human neurological features in Alzheimer’s diseaseFrom1 Jan 2023 → TodayFunding: FWO fellowships
- A vicious Aβ oligomers-dependent neuron-microglia cycle fuels Alzheimer's DiseaseFrom1 Jan 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Human-mouse neuronal xenografts to study incipient Alzheimer’s Disease.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The early microglia–neuron interactions in Alzheimer’s Disease and their modulation by immunotherapyFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's diseaseFrom1 May 2022 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
- Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse modelFrom24 Jan 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Genetic Risk in Alzheimer's diseaseFrom14 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Functional characterization of human neurons in the human-mouse chimeric model for Alzheimer’s diseaseFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
261 - 270 of 330
- Parkin interacts with Ambra1 to induce mitophagy(2011)
Authors: C Van Humbeeck, T Cornelissen, H Hofkens, W Mandemakers, K Gevaert, Bart De Strooper, W Vandenberghe, Wim Vandenberghe
Pages: S29 - S29 - Deletion of Aph1B subunit of the gamma-secretase complex creates a novel mouse model for schizophrenia(2011)
Authors: Bart De Strooper, Rudi D'Hooge
Number of pages: 111 - Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex(2011)
Authors: Leen Bammens, Lucia Chavez Gutierrez, Alexandra Tolia, An Zwijsen, Bart De Strooper
- The disintegrin/metalloproteinase ADAM10 controls epidermal Notch signaling and skin homeostasis(2011)
Authors: S Weber, MT Niessen, J Prox, R Luellmann-Rauch, R Schwanbeck, CP Blobel, E Jorissen, Bart De Strooper, CM Niessen, P Saftig
Pages: S57 - S57 - Inhibition of β-secretase in vivo via antibody binding to unique loops (D and F) of BACE1(2011)
Authors: L Zhou, L Chávez-Gutiérrez, K Bockstael, R Sannerud, Wim Annaert, PC May, E Karran, Bart De Strooper
Pages: 8677 - 8687 - Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation(2011)
Authors: Lujia Zhou, Koen Van Laere, Fred Van Leuven, Rik Vandenberghe, Bart De Strooper
Pages: 291 - 302 - Inhibition of {beta}-secretase in vivo via antibody binding to unique loops (D and F) of BACE1(2011)
Authors: Lujia Zhou, Lucia Chavez Gutierrez, Katrijn Bockstael, Wim Annaert, Bart De Strooper
Pages: 8677 - 8687 - The role of G protein-coupled receptors in the pathology of Alzheimer's disease(2011)
Authors: Amantha Thathiah, Bart De Strooper
Pages: 73 - 87 - The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling(2011)
Authors: Ellen Jorissen, Bart De Strooper
Pages: 495 - 505 - Analysis of ADAM10 in neurodevelopment and as a candidate alpha-secretase in Alzheimer's disease(2011)
Authors: Bart De Strooper
Number of pages: 94
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)