Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 668
- Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis(2019)
Authors: Diether Lambrechts, Patrick Neven, Ann Smeets, Hans Wildiers
Pages: 795 - 806 - Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers(2023)
Authors: Diether Lambrechts, Ingrid Arijs
Pages: 1327 - 1338 - Genome-wide association study of germline variants and breast cancer-specific mortality(2019)
Authors: Bram Boeckx, Eva Galle, Diether Lambrechts, Ann Smeets
Pages: 647 - 657 - BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers(2016)
Authors: Diether Lambrechts, Patrick Neven
- Multi-omics mapping positions antigenic myeloid-T cell crosstalk at the core of advanced renal cell carcinoma (aRCC) response to immune checkpoint blockade (ICB)(2023)
Authors: Lisa Kinget, Isaure Vanmeerbeek, Diether Lambrechts, Bram Boeckx, Maarten Albersen, Sabine Tejpar, Benoit Beuselinck, Abhishek Garg
Pages: S1026 - S1027 - Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers(2016)
Authors: Dominique Schols, Christel Meuleman, Karen Peeraer, Carla Tomassetti, Xavier Bossuyt, Diether Lambrechts, Thomas D'Hooghe, Amelie Fassbender
Pages: 988 - 996 - Common variants at 19p13 are associated with susceptibility to ovarian cancer (vol 42, pg 880, 2010)(2016)
Authors: Kelly L Bolton, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya-Yu Tsai, et al.
Pages: 101 - 101 - Het sequeneren van tumoren deficiënt in mismatch-herstelmechanismen identificeert een synthetisch dodelijke interactie met PARP inhibitie(2014)
Authors: Diether Lambrechts
- Clinical and genetic risk factors for epirubicin-induced cardiac toxicity in early breast cancer patients(2015)
Authors: Christof Vulsteke, Alena M Pfeil, Charlotte Maggen, Matthias Schwenkglenks, Ruth Pettengell, Thomas D Szucs, Diether Lambrechts, Anne-Sophie Dieudonné, Sigrid Hatse, Patrick Neven, et al.
Pages: 67 - 76 - Identification of nine new susceptibility loci for endometrial cancer(2018)
Authors: Frédéric Amant, Daniela Annibali, Diether Lambrechts, Adriaan Vanderstichele