Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 668
- Clinical practice guidelines for BRCA1and BRCA2 genetic testing(2021)
Authors: Diether Lambrechts, Ignace Vergote
Pages: 30 - 47 - Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome(2014)
Authors: Ignace Vergote, Sandrina Lambrechts, Diether Lambrechts
Pages: 332 - 340 - Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome and genetic determinants of vitamin D insufficiency(2012)
Authors: Sigrid Hatse, Diether Lambrechts, Mieke Verstuyf, Ann Smeets, Annouschka Laenen, Lieve Verlinden, Anne-Sophie Dieudonné, Robert Paridaens, Patrick Neven, Rose Christiaens, et al.
Pages: 1319 - 1326 - New molecular insights based on genetic alterations in gynecological cancers.(2017)
Authors: Jeroen Depreeuw, Diether Lambrechts, Frédéric Amant
- Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer(2016)
Authors: Shalaka S Hampras, Lara E Sucheston-Campbell, Rikki Cannioto, Jenny Chang-Claude, Francesmary Modugno, Thilo Dörk, Peter Hillemanns, Leah Preus, Keith L Knutson, Paul K Wallace, et al.
Pages: 69087 - 69110 - The 15q24/25 Susceptibility Variant for Lung Cancer and Chronic Obstructive Pulmonary Disease Is Associated with Emphysema(2010)
Authors: Diether Lambrechts, Johan Coolen, Harry Cuppens, Johny Verschakelen, Marc Decramer, Wim Janssens
Pages: 486 - 493 - Genome-wide association study identifies a common variant associated with risk of endometrial cancer(2011)
Authors: Diether Lambrechts, Lieve Coenegrachts, Ignace Vergote, Frédéric Amant
Pages: 451 - 454 - Shared genetics underlying epidemiological association between endometriosis and ovarian cancer(2015)
Authors: Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Adriaan Vanderstichele
Pages: 5955 - 64 - Identification of new genetic susceptibility Loci for breast cancer through consideration of gene-environment interactions(2014)
Authors: Matthieu Moisse, Patrick Neven, Hans Wildiers, Diether Lambrechts
Pages: 84 - 93 - Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)(2012)
Authors: Diether Lambrechts, Hui Zhao, Patrick Neven, Hans Wildiers