Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Projects
11 - 20 of 72
- Alternative RNA splicing as a predictor of response to checkpoint immunotherapyFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Exploring the reciprocal crosstalk between the vasculature in cancer to improve immunotherapyFrom15 Feb 2021 → TodayFunding: FWO fellowships, Foundations, funds and other with scientific goal
- Single-cell omics data analysis in translational oncologyFrom1 Feb 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Epigenetic and Spatial Single-cell profiling in the context of Cancer ImmunotherapyFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- EU-Genomics: EU Infrastructure for Genome AnalysisFrom1 Jan 2021 → TodayFunding: FWO Large scale research infrastructure
- Resistance under treatment in breast cancerFrom1 Sep 2020 → TodayFunding: FWO research project (including WEAVE projects)
- Exploring the heterogeneity of rare ovarian cancerDefining (epi)genomic transition from precursor lesion to invasive rare ovarian cancerFrom1 Apr 2020 → 1 Apr 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- T Cell Expansion and Tumour Neoantigen Evolution during Checkpoint ImmunotherapyFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- The search for biomarkers in systemic treatment of advanced hepatocellular carcinoma.From1 Oct 2019 → 1 Oct 2023Funding: FWO Strategic Basic Research Grant
Publications
1 - 10 of 667
- LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin β3 axis(2019)
Authors: Junbin Qian
Pages: 4851 - 4862 - Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation.(2023)
Authors: Bram Boeckx
Pages: 355 - 365 - Insm1 regulates mTEC development and immune tolerance(2023)
Authors: Jieyi Xiong
Pages: 1472 - 1486 - The AI-2 dependent regulator LsrR has a limited regulon in Salmonella Typhimurium(2010)
Authors: Inge Thijs, Hui Zhao, Kristof Engelen, Jos Vanderleyden, Kathleen Marchal, Sigrid De Keersmaecker
Pages: 966 - 969 - Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium(2016)
Authors: Laurien Van Dyck, Ann Smeets
Pages: 137 - 154 - Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.(2018)
Authors: Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, et al.
Pages: 1123 - 1129 - A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (vol 12, 1078, 2021)(2021)
Authors: Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, et al.
- Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF delta/delta mouse model of amyotrophic lateral sclerosis(2010)
Authors: Filip Claes, Diether Lambrechts, Peter Carmeliet
Pages: 203 - The old antibiotic acriflavine inhibits epithelial-to-mesenchymal transition and the unfolded protein response thereby resensitizing resistant hepatoma cells to sorafenib(2016)
Authors: Jeroen Dekervel, Ashenafi Shiferaw Bulle, Petra Windmolders, Diether Lambrechts, Eric Van Cutsem, Chris Verslype
Pages: 245 - Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma(2021)
Authors: Michael Dewaele, Panagiotis Karras, Nina Van Raemdonck, Dennis Pedri, Jonas Demeulemeester, Sara Vander Borght, Francesca Bosisio, Joost van den Oord, Isabelle Vanden Bempt, Diether Lambrechts, et al.
Pages: 1135 - +