Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Projects
31 - 40 of 71
- Mapping intratumoral dynamics during immune checkpoint blockade in breast cancer by single-cell profilingFrom9 Jan 2018 → 16 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding intra-tumor heterogeneity and its implication in therapeutic resistance with spatial transcriptomics in space and timeFrom1 Jan 2018 → 1 Jan 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Optimization and validation of mRNA biomarkers for antibody-mediated rejection after kidney transplantationFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
- Circulating tumor DNA as an epigenetic marker of tumor behaviourFrom1 Jul 2017 → 30 Jun 2020Funding: Private funding of national origin - undefined
- Comprehensive transcriptomic analysis of high-grade serous tubo-ovarian carcinoma using single-cell RNA-sequencing.From1 Mar 2017 → 5 Jul 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- A Nanopore Long-read Sequencing-based Approach to more Accurately Detect Predictive Biomarkers for Cancer ImmunotherapyFrom1 Jan 2017 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Towards petascale biocomputational sciencesFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Molecular profiling of clear-cell renal cell carcinoma and prediction of response to targeted therapies against the vascular endothelial growth factor receptor, immune checkpoint inhibitors and mTOR inhibitors in the metastatic setting.From1 Oct 2016 → 30 Sep 2020Funding: FWO fellowships, Nonprofit institution or equivalents
- DNA methylation dynamics underlying therapy resistance in cancerFrom1 Oct 2015 → 23 Jun 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- CRYPTIC TRANSCRIPTS: THE MASKED HEROES WHO BREAK TUMOR IMMUNE TOLERANCE AND FREE THE RESPONSE TO IMMUNE THERAPY.From1 Oct 2015 → 31 Jul 2021Funding: FWO fellowships
Publications
1 - 10 of 664
- Locus-specific induction of gene expression from heterochromatin loci during cellular senescence(2022)
Authors: Dóra Bihary
Pages: 31 - + - Dysphagia during glucocorticoid treatment of dermatomyositis: a differential diagnostic challenge(2018)
Authors: Pierre Van Mol, Ellen De Langhe, Patrick Verschueren
- Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry(2016)
Authors: Patrick Neven, Hui Zhao
Pages: 679 - 693 - A theoretical and matrix-isolation FT-IR investigation of the conformational landscape of N-acetylcysteine(2010)
Authors: Bram Boeckx, Guido Maes
Pages: 73 - 81 - Capmatinib for the treatment of non-small cell lung cancer(2019)
Authors: Johan Vansteenkiste, Els Wauters, Pierre Van Mol
Pages: 659 - 671 - Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19(2020)
Authors: Julika Neumann, Lore Vanderbeke, Margaux Gerbaux, Pierre Van Mol, Yannick Van Herck, Joost Wauters, Els Wauters, Adrian Liston, Stephanie Humblet-Baron
- SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants(2012)
Authors: Greet De Baets, Joost Van Durme, Joke Reumers, Joost Schymkowitz, Frederic Rousseau
Pages: D935 - D939 - Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium(2019)
Authors: Bram Boeckx, Frans Van de Werf, Els Wauters, Diether Lambrechts
- Genetic Predisposition Scores Associate with Muscular Strength, Size, and Trainability(2013)
Authors: Tom Thomaes, Martine Thomis, Steven Onkelinx, Kaatje Goetschalckx, Robert Fagard, Diether Lambrechts, Luc Vanhees
Pages: 1451 - 1459 - The diagnostic value of next generation sequencing in familial nonsyndromic congenital heart defects(2015)
Authors: Yaojuan Jia, Jacoba J Louw, Jeroen Breckpot, Bert Callewaert, Catherine Barrea, Yves Sznajer, Erika Souche, Luc Dehaspe, Joris Vermeesch, Diether Lambrechts, et al.
Pages: 1822 - 9