Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 71
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 664
- rs2735383, located at a microRNA binding site in the 3′UTR of NBS1, is not associated with breast cancer risk(2016)
Authors: Bram Boeckx, Sigrid Hatse
- Query-based biclustering of gene expression data using Probabilistic Relational Models(2011)
Authors: Hui Zhao, Lore Cloots, Yan Wu, Riet De Smet, Valerie Storms, Pieter Meysman, Kristof Engelen, Kathleen Marchal
- RAD51B in Familial Breast Cancer(2016)
Authors: Laurien Van Dyck, Hilde Janssen
- MicroRNA Related Polymorphisms and Breast Cancer Risk(2014)
Authors: Diether Lambrechts, Matthieu Moisse, Robert Paridaens, Rose Christiaens
- Identification and prioritization of NUAK1 and PPP1CC as positional candidate loci for skeletal muscle strength phenotypes(2011)
Authors: Maarten Peeters, Diether Lambrechts, Robert Vlietinck, Gaston Beunen, Martine Thomis
Pages: 981 - 992 - Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer(2011)
Authors: Erik Van Limbergen, Hilde Janssen, Diether Lambrechts
Pages: 6240 - 6249 - NEXT GENERATION SEQUENCING: A TOOL TO REVEAL THE GENETIC ORIGIN OF HUMAN DISEASES(2015)
Authors: Matthieu Moisse, Diether Lambrechts
Number of pages: 166 - Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)(2016)
Authors: Eva Galle, Diether Lambrechts
Pages: 32512 - The genomic landscape of nonsmall cell lung carcinoma in never smokers(2020)
Authors: Bram Boeckx, Diether Lambrechts
Pages: 3207 - 3218 - Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells(2023)
Authors: Lore Hoes, Karin Voordeckers, Rüveyda Dok, Bram Boeckx, Sander Govers, Diether Lambrechts, Sandra Nuyts, Kevin Verstrepen