Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Projects
21 - 30 of 72
- Single-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerSingle-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerSingle-Cell Omics to Reveal Mechanisms of Response to Immunotherapy in Head and Neck CancerFrom1 Sep 2019 → 1 Sep 2023Funding: Foundations, funds and other with scientific goal
- A single-cell approach to identify biomarkers of efficacy and toxicity for immune checkpoint blockade in non-small cell lung cancer.From1 Aug 2019 → 1 Aug 2023Funding: FWO Strategic Basic Research Grant, Foundations, funds and other with scientific goal
- Predictive genetic markers for targeted therapy in gynaecological malignancies: bridging the gap between “one-size-fits-all” and more personalised treatment approach.From1 Aug 2019 → 11 Oct 2023Funding: FWO Strategic Basic Research Grant
- Integrated IMMUnoprofiling of large adaptive CANcer patients cohortsFrom1 Mar 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing, H2020 - European Institute of Innovation and Technology
- Dissecting complex tumor microenvironment dynamics during immune checkpoint inhibition using single-cell profilingFrom1 Jan 2019 → 31 Dec 2021Funding: Foundations, funds and other with scientific goal
- Unraveling the resistance mechanisms to PI3K/mTOR inhibition and PD-1 blockade in uterine leiomyosarcomaFrom1 Dec 2018 → 30 Nov 2023Funding: Foundations, funds and other with scientific goal
- Genomic Driven Approach to Identify Molecular Biomarkers and Therapeutic Targets for GlioblastomaFrom29 Oct 2018 → 4 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally disentangling cellular heterogeneityFrom1 Oct 2018 → 30 Sep 2022Funding: Fund Recuperation Fiscal Exemption
- Novel applications for immune checkpoint blockers in head and neck cancerFrom1 Sep 2018 → 19 Mar 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Single-cell omics in high throughput and at spatial resolutionFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 667
- LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin β3 axis(2019)
Authors: Junbin Qian
Pages: 4851 - 4862 - Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation.(2023)
Authors: Bram Boeckx
Pages: 355 - 365 - Insm1 regulates mTEC development and immune tolerance(2023)
Authors: Jieyi Xiong
Pages: 1472 - 1486 - The AI-2 dependent regulator LsrR has a limited regulon in Salmonella Typhimurium(2010)
Authors: Inge Thijs, Hui Zhao, Kristof Engelen, Jos Vanderleyden, Kathleen Marchal, Sigrid De Keersmaecker
Pages: 966 - 969 - Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium(2016)
Authors: Laurien Van Dyck, Ann Smeets
Pages: 137 - 154 - Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.(2018)
Authors: Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, et al.
Pages: 1123 - 1129 - A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (vol 12, 1078, 2021)(2021)
Authors: Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, et al.
- Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF delta/delta mouse model of amyotrophic lateral sclerosis(2010)
Authors: Filip Claes, Diether Lambrechts, Peter Carmeliet
Pages: 203 - The old antibiotic acriflavine inhibits epithelial-to-mesenchymal transition and the unfolded protein response thereby resensitizing resistant hepatoma cells to sorafenib(2016)
Authors: Jeroen Dekervel, Ashenafi Shiferaw Bulle, Petra Windmolders, Diether Lambrechts, Eric Van Cutsem, Chris Verslype
Pages: 245 - Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma(2021)
Authors: Michael Dewaele, Panagiotis Karras, Nina Van Raemdonck, Dennis Pedri, Jonas Demeulemeester, Sara Vander Borght, Francesca Bosisio, Joost van den Oord, Isabelle Vanden Bempt, Diether Lambrechts, et al.
Pages: 1135 - +