Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 668
- Locus-specific induction of gene expression from heterochromatin loci during cellular senescence(2022)
Authors: Dóra Bihary
Pages: 31 - + - Dysphagia during glucocorticoid treatment of dermatomyositis: a differential diagnostic challenge(2018)
Authors: Pierre Van Mol, Ellen De Langhe, Patrick Verschueren
- Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry(2016)
Authors: Patrick Neven, Hui Zhao
Pages: 679 - 693 - A theoretical and matrix-isolation FT-IR investigation of the conformational landscape of N-acetylcysteine(2010)
Authors: Bram Boeckx, Guido Maes
Pages: 73 - 81 - Capmatinib for the treatment of non-small cell lung cancer(2019)
Authors: Johan Vansteenkiste, Els Wauters, Pierre Van Mol
Pages: 659 - 671 - Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19(2020)
Authors: Julika Neumann, Lore Vanderbeke, Margaux Gerbaux, Pierre Van Mol, Yannick Van Herck, Joost Wauters, Els Wauters, Adrian Liston, Stephanie Humblet-Baron
- SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants(2012)
Authors: Greet De Baets, Joost Van Durme, Joke Reumers, Joost Schymkowitz, Frederic Rousseau
Pages: D935 - D939 - Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium(2019)
Authors: Bram Boeckx, Frans Van de Werf, Els Wauters, Diether Lambrechts
- Genetic Predisposition Scores Associate with Muscular Strength, Size, and Trainability(2013)
Authors: Tom Thomaes, Martine Thomis, Steven Onkelinx, Kaatje Goetschalckx, Robert Fagard, Diether Lambrechts, Luc Vanhees
Pages: 1451 - 1459 - The diagnostic value of next generation sequencing in familial nonsyndromic congenital heart defects(2015)
Authors: Yaojuan Jia, Jacoba J Louw, Jeroen Breckpot, Bert Callewaert, Catherine Barrea, Yves Sznajer, Erika Souche, Luc Dehaspe, Joris Vermeesch, Diether Lambrechts, et al.
Pages: 1822 - 9