Validatie van het oxadiazolon isosteer als een carboxylaatvervangende groep in caspase inhibitoren: benaderingen gebaseerd op optimalisatie van Strecker-afgeleide methodologieën en "ontarget" strategieën. Universiteit Antwerpen
Caspases are intracellular, aspartate selective cysteine proteases. Given their central role in cell death and inflammation, caspases have been studied intensively as drug targets to date. Most attention so far has gone to caspases 1 and 3: these are generally considered to be the prime end-effectors of cellular inflammation and apoptosis pathways, respectively.2 In spite of impressive preclinical results and significant investment in clinical ...