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Onderzoeker
Jan Balzarini
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 okt 1999 → 30 sep 2016
Projecten
1 - 6 of 6
- Exploratie van suiker-bindende stoffen en (co)receptor inhibitoren gericht tegen HIV.Vanaf1 jan 2012 → 31 dec 2017Financiering: FWO Onderzoeksproject (incl. WEAVE projecten)
- Onderzoek naar de rol van de HIV enveloppe glycanen in de virale infectie en de antivrale activiteit van suiker-bindende moleculen.Vanaf29 sep 2011 → 30 sep 2015Financiering: FWO mandaten
- Het Rev-afhankelijke nucleocytoplasmatisch mRNA-transport als nieuw doelwit voor anti-HIV therapieVanaf1 jan 2011 → 2 jun 2015Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
- Virale infecties: moleculaire inzichten, doel voor interventie en medicatie ontwikkelingVanaf1 nov 2010 → 31 okt 2018Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Effect van Mycoplasma-enzymen op de antivirale en anti-kanker activiteit van nucleoside-analogen.Vanaf1 jun 2008 → 2 dec 2013Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
Publicaties
11 - 20 van 547
- Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity(2019)
Auteurs: Sam Noppen, Sandra Liekens, Jan Balzarini
Pagina's: 390 - 398 - Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes(2019)
Auteurs: Jan Balzarini
- Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases(2019)
Auteurs: Jan Balzarini, Kalyan Das, Wim Dehaen
Pagina's: 137 - 154 - Synthesis of Heterocyclic Triterpene Derivatives with Biological Activities via Click Reaction(2019)
Auteurs: Wim Dehaen, Luc Van Meervelt, Jan Balzarini
Pagina's: 2969 - 2974 - Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells(2019)
Auteurs: Jan Balzarini
Pagina's: 430 - 438 - Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5 '-Monophosphate Forms of Anticancer Nucleoside Analogues(2018)
Auteurs: Jan Balzarini
Pagina's: 2305 - 2316 - Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin(2018)
Auteurs: Mariya Petrova, Jan Balzarini, Jos Vanderleyden, Dominique Schols, Sarah Lebeer
Pagina's: 599 - 607 - Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units(2018)
Auteurs: Jan Balzarini, Dominique Schols
- Synthesis of Guanine α-Carboxy Nucleoside Phosphonate (G-α-CNP), a Direct Inhibitor of Multiple Viral DNA Polymerases(2018)
Auteurs: Jan Balzarini
Pagina's: 10510 - 10517 - Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach(2018)
Auteurs: Jan Balzarini, Sandra Liekens, Dominique Schols
Pagina's: 1225 - 1238
Patenten
1 - 10 van 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)