Onderzoeker
Jan Balzarini
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 okt 1999 → 30 sep 2016
Projecten
1 - 6 of 6
- Exploratie van suiker-bindende stoffen en (co)receptor inhibitoren gericht tegen HIV.Vanaf1 jan 2012 → 31 dec 2017Financiering: FWO Onderzoeksproject (incl. WEAVE projecten)
- Onderzoek naar de rol van de HIV enveloppe glycanen in de virale infectie en de antivrale activiteit van suiker-bindende moleculen.Vanaf29 sep 2011 → 30 sep 2015Financiering: FWO mandaten
- Het Rev-afhankelijke nucleocytoplasmatisch mRNA-transport als nieuw doelwit voor anti-HIV therapieVanaf1 jan 2011 → 2 jun 2015Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
- Virale infecties: moleculaire inzichten, doel voor interventie en medicatie ontwikkelingVanaf1 nov 2010 → 31 okt 2018Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Effect van Mycoplasma-enzymen op de antivirale en anti-kanker activiteit van nucleoside-analogen.Vanaf1 jun 2008 → 2 dec 2013Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
Publicaties
31 - 40 van 547
- Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes(2017)
Auteurs: Els Vanstreels, Wim Dehaen, Sandra Liekens, Jan Balzarini
Pagina's: 219 - 235 - A multitarget approach toward the development of 8-substituted purines for photoprotection and prevention of UV-related damage(2017)
Auteurs: Jan Balzarini, Sandra Liekens
Pagina's: 760 - 769 - 6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins(2017)
Auteurs: Jan Balzarini, Erik De Clercq
Pagina's: 1611 - 1615 - Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid(2017)
Auteurs: Liang Sun, Jan Balzarini, Sam Noppen, Sandra Liekens, Dominique Schols, Johan Neyts, Pieter Leyssen, Carmen Mirabelli
Pagina's: 32 - 40 - Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products (vol 15, pg 1130, 2017)(2017)
Auteurs: Hari K Akula, Hariprasad Kokatla, Graciela Andrei, Robert Snoeck, Dominique Schols, Jan Balzarini, Lijia Yang, Mahesh K Lakshman
Pagina's: 1268 - 1268 - Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products(2017)
Auteurs: Graciela Andrei, Robert Snoeck, Dominique Schols, Jan Balzarini
Pagina's: 1130 - 1139 - ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites(2016)
Auteurs: Jan Balzarini
Pagina's: 5618 - 5623 - Novel isoxazolidine analogues of homonucleosides and homonucleotides(2016)
Auteurs: Jan Balzarini, Graciela Andrei, Dominique Schols, Robert Snoeck
Pagina's: 8294 - 8308 - Niacin esters of chalcones with tumor-selective properties(2016)
Auteurs: Jan Balzarini, Erik De Clercq
Pagina's: 1451 - 1456 - Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis Binding of Foscarnet (vol 11, pg 2158, 2016)(2016)
Auteurs: Kalyan Das, Jan Balzarini, Matthew T Miller, Anita R Maguire, Jeffrey J DeStefano, Eddy Arnold
Pagina's: 3226 - 3226
Patenten
1 - 10 van 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)