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Onderzoeker
Jan Balzarini
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 okt 1999 → 30 sep 2016
Projecten
1 - 6 of 6
- Exploratie van suiker-bindende stoffen en (co)receptor inhibitoren gericht tegen HIV.Vanaf1 jan 2012 → 31 dec 2017Financiering: FWO Onderzoeksproject (incl. WEAVE projecten)
- Onderzoek naar de rol van de HIV enveloppe glycanen in de virale infectie en de antivrale activiteit van suiker-bindende moleculen.Vanaf29 sep 2011 → 30 sep 2015Financiering: FWO mandaten
- Het Rev-afhankelijke nucleocytoplasmatisch mRNA-transport als nieuw doelwit voor anti-HIV therapieVanaf1 jan 2011 → 2 jun 2015Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
- Virale infecties: moleculaire inzichten, doel voor interventie en medicatie ontwikkelingVanaf1 nov 2010 → 31 okt 2018Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Effect van Mycoplasma-enzymen op de antivirale en anti-kanker activiteit van nucleoside-analogen.Vanaf1 jun 2008 → 2 dec 2013Financiering: IWT persoonsgebonden financ. - strategische onderzoeksbeurzen
Publicaties
21 - 30 van 547
- The ProTide Prodrug Technology: From the Concept to the Clinic(2018)
Auteurs: Jan Balzarini
Pagina's: 2211 - 2226 - 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells(2018)
Auteurs: Sam Noppen, Wim Dehaen, Jan Balzarini, Sandra Liekens
Pagina's: 6259 - 6269 - 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition(2018)
Auteurs: Jan Balzarini, Sandra Liekens
Pagina's: 683 - 698 - Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases (vol. 33, pg. 775, 2017)(2017)
Auteurs: Victor M Castillo-Acosta, Jan Balzarini, Dolores Gonzalez-Pacanowska
Pagina's: 1003 - 1004 - Surface glycans: A therapeutic opportunity for kinetoplastid diseases(2017)
Auteurs: Jan Balzarini
Pagina's: 775 - 787 - New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity(2017)
Auteurs: Robert Snoeck, Jan Balzarini, Graciela Andrei
Pagina's: 4637 - 4648 - Virtual screening of acyclovir derivatives as potential antiviral agents: Design, synthesis, and biological evaluation of new acyclic nucleoside ProTides(2017)
Auteurs: Graciela Andrei, Robert Snoeck, Jan Balzarini
Pagina's: 7876 - 7896 - Synthesis and biological activity of novel phenol-conjugates of isoxazolidines(2017)
Auteurs: Jan Balzarini, Graciela Andrei, Dominique Schols, Robert Snoeck
Pagina's: 1091 - 1100 - Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses(2017)
Auteurs: Jan Balzarini, Kalyan Das, Sandra Liekens
Pagina's: 51 - 61 - A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes(2017)
Auteurs: Sampad Jana, Jan Balzarini, Sandra Liekens, Wim Dehaen
Pagina's: 3892 - 3900
Patenten
1 - 10 van 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)