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Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
11 - 20 of 547
- Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity(2019)
Authors: Sam Noppen, Sandra Liekens, Jan Balzarini
Pages: 390 - 398 - Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes(2019)
Authors: Jan Balzarini
- Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases(2019)
Authors: Jan Balzarini, Kalyan Das, Wim Dehaen
Pages: 137 - 154 - Synthesis of Heterocyclic Triterpene Derivatives with Biological Activities via Click Reaction(2019)
Authors: Wim Dehaen, Luc Van Meervelt, Jan Balzarini
Pages: 2969 - 2974 - Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells(2019)
Authors: Jan Balzarini
Pages: 430 - 438 - Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5 '-Monophosphate Forms of Anticancer Nucleoside Analogues(2018)
Authors: Jan Balzarini
Pages: 2305 - 2316 - Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin(2018)
Authors: Mariya Petrova, Jan Balzarini, Jos Vanderleyden, Dominique Schols, Sarah Lebeer
Pages: 599 - 607 - Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units(2018)
Authors: Jan Balzarini, Dominique Schols
- Synthesis of Guanine α-Carboxy Nucleoside Phosphonate (G-α-CNP), a Direct Inhibitor of Multiple Viral DNA Polymerases(2018)
Authors: Jan Balzarini
Pages: 10510 - 10517 - Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach(2018)
Authors: Jan Balzarini, Sandra Liekens, Dominique Schols
Pages: 1225 - 1238
Patents
1 - 10 of 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)