Projects
Improving treatment strategies for different depressive disorders by discovery of novel drug target candidates and discriminatory diagnostic biomarkers. University of Antwerp
Extending the Amalus drug discovery program: validation studies for immuno-oncological and fibrosis indications to increase the IP and investment value Ghent University
In the Amalus drug discovery program (StepStone), we pursue the establishment of a spin-off company to progress cell-selective inhibitors to clinical trials. This ConcepTT project will increase the IP and investment value of the program.
Our inhibitors possess unique features with respect to competition and represent a first-in-class opportunity.
As single agents, our molecules inhibit metastasis in vivo. In the StepStone ...
Drug discovery for Parkinson’s disease using a translational screening platform KU Leuven
Financing IOF-program: ConFoBodies to uncover protein-protein interactions for drug discovery Vrije Universiteit Brussel
Purification of the Secretory Pathway Ca2+/Mn2+ ATPases for Functional Analysis and Drug Discovery KU Leuven
The organellar P2-type Ca2+-transport ATPases, namely Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and Secretory Pathway Ca²⁺ ATPase (SPCA), are essential to maintain a low resting cytosolic Ca2+ level. At the same time they load respectively the intracellular endoplasmic reticulum (ER) and Golgi stores with Ca2+. This allows Ca2+ signaling to occur and it supports several organellar processes such as protein folding and maturation. ...
Improving treatment strategies for bipolar disorder by discovery of novel drug target candidates and discriminatory diagnostic biomarkers. University of Antwerp
RNA biomarkers discovery for ultra-fast drug synergy and susceptibility testing in the mycobacterium avium complex. University of Antwerp
Venomics and transcriptomics of Conus spp.: an untapped treasure for drug discovery. KU Leuven
Pharmacological feasibility of a drug discovery opportunity for a novel cancer immunotherapy Ghent University
Targeted activation of one's own immune system is a new therapeutic approach to cancer treatment in which the pharmaceutical industry is showing increasing interest. Our research groups developed new glycolipids as antigens. With this ConcepTT project we want to subject 3 analogues to in vitro ADME / Tox tests and an in vivo PK study (based on industry standards). An initial series of discussions with companies shows that this information is ...