Researcher
Pieter Van Der Veken
- Research interest:Medicinal chemistry & drug discovery, pharmaceutical chemistry, organic chemistry & organic synthesis
- Keywords:ORGANIC CHEMISTRY, MEDICINAL CHEMISTRY, DRUG DISCOVERY, Pharmacy and pharmacology
- Disciplines:(Bio)molecular modelling and design, Characterisation of biologically active (macro)molecules, Medicinal and biomolecular chemistry not elsewhere classified, Bio-organic chemistry, Organic chemical synthesis, Medicinal chemistry
- Research techniques:Drug design, organic synthesis, characterization of molecules via NMR spectroscopy, mass spectrometry and other analytical techniques
- Users of research expertise:Pharmaceutical and biotech-industry
Affiliations
- Medicinal Chemistry (UAMC) (Research group)
Member
From1 Oct 2003 → Today
Projects
1 - 10 of 53 results
- The role of dipeptidyl peptidase 9 (DPP9) in human monocyte-derived macrophages: Discovery of DPP9 binding partners & natural substrates using novel chemical and cellular tools.From1 Jan 2021 → TodayFunding: FWO research project
- Treatment of autophagy deficits in Charcot-Marie-Tooth disease caused by mutations in the small heat shock proteins HSPB1 and HSPB8.From1 Jan 2021 → TodayFunding: FWO research project
- Validation of autophagy induction as a therapeutic strategy: from drug discovery and preclinical evaluation to safety investigation and biomarker research.From1 Jan 2021 → TodayFunding: BOF - projects
- Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basicinsights to experimental therapy.From1 Jan 2021 → TodayFunding: BOF - iBOF
- Exploring a novel class of autophagy-inducing small molecules: chemical/biological investigation, target identification and validation in a mouse model of atherosclerosis.From1 Nov 2020 → TodayFunding: FWO senior postdoctoral fellowship
- Biopharmaceutical optimization of PET-diagnostic tools targeting fibroblast activation protein (FAP).From1 May 2020 → 30 Sep 2021Funding: IOF - technology validation in lab
- Cell death detection platform.From1 Jan 2020 → TodayFunding: BOF - scientific equipment program
- Pharmacological modulation of autophagy in vascular disease.From1 Dec 2019 → TodayFunding: BOF - projects
- Development of tools and methods for the evaluation of FAP as a predictive/prognostic biomarker in cancer.From1 Nov 2019 → 30 Oct 2021Funding: FWO Strategic Basic Research Grant
- Personalized immune therapy: FAP as a marker for resistance to immune checkpoint therapy in urothelial carcinomas.From1 Sep 2019 → TodayFunding: VLAIO - research project companies
Publications
1 - 10 of 105 results
- In vitro and in situ activity-based labeling of fibroblast activation protein with UAMC1110-derived probes(2021)
Authors: Yentl Van Rymenant, Muhammet Tanc, Roos Van Elzen, An Bracke, Olivier De Wever, Koen Augustyns, Anne-Marie Lambeir, Mark M. Kockx, Ingrid De Meester, Pieter Paula Frans Van Der Veken
Number of pages: 12 - Strecker-derived methodology for library synthesis of N-acylated alpha-aminonitriles(2021)
Authors: Pedro Goncalves, Anke Peeraer, Yves Adriaenssens, Lara Zonnekein, Philippe Franck, Bert Maes, Koen Augustyns, Pieter Paula Frans Van Der Veken
Pages: 1328 - 1338 - Profiling and structural investigation of dihydrotriazine-based DHFR inhibitors and hydantoin-derived DprE1 inhibitors in search of novel antimycobacterials(2021)Edition: 99Volume: 99
Authors: Olga Balabon, Koen Augustyns, Pieter Paula Frans Van Der Veken, Robert Bates
Number of pages: 215 - Optimization of hydantoins as potent antimycobacterial decaprenylphosphoryl-β-D-ribose oxidase (DprE1) inhibitors(2020)
Authors: Olga Balabon, Eleni Pitta, Maciej Rogacki, Eugenia Meiler, Ruth Casanueva, Laura Guijarro, Sophie Huss, Eva Maria Lopez-Roman, Angel Santos-Villarejo, Koen Augustyns, et al.
Pages: 5367 - 5386 - Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice(2020)
Authors: Paola Perrotta, Bieke Van der Veken, Pieter Paula Frans Van Der Veken, Isabel Pintelon, Laurence Roosens, Elias Adriaenssens, Vincent Timmerman, Pieter-Jan Guns, Guido De Meyer, Wim Martinet
Pages: 1168 - 1181 - Lead optimization of phthalazinone phosphodiesterase inhibitors as novel antitrypanosomal compounds(2020)
Authors: Irene Garcìa Salado, Abhimanyu K. Singh, Carlos Moreno Cinos, Guna Sakaine, Marco Siderius, Pieter Paula Frans Van Der Veken, An Matheeussen, Tiffany van der Meer, Payman Sadek, Sheraz Gul, et al.
Pages: 3485 - 3507 - Preclinical evaluation of a novel ¹⁸F-labeled dTCO-amide derivative for bioorthogonal pretargeted positron emission tomography imaging(2020)
Authors: Eduardo Ruivo, Filipe Elvas, Karuna Adhikari, Christel Vangestel, Glenn Van Haesendonck, Filip Lemière, Steven Staelens, Sigrid Stroobants, Pieter Paula Frans Van Der Veken, Leonie Wyffels, et al.
Pages: 4449 - 4456 - Development of novel chemical tools for bioorthogonal pretargeted PET imaging(2020)Edition: 99Volume: 99
Authors: Eduardo Ruivo, Koen Augustyns, Pieter Paula Frans Van Der Veken, Leonie Wyffels
Number of pages: 226 - Targeting fibroblast activation protein (FAP)(2020)
Authors: Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, et al.
Pages: 1 - 20 - Novel small molecule-derived, highly selective substrates for fibroblast activation protein (FAP)(2019)
Authors: An De Decker, Gwendolyn Vliegen, Dries Van Rompaey, Anke Peeraer, An Bracke, Line Verckist, Koen Jansen, Ruth Geiss-Friedlander, Koen Augustyns, Hans De Winter, et al.
Pages: 1173 - 1179