Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 22 results
- Ion channel ligands with unique selectivityFrom1 Jan 2020 → TodayFunding: FWO research project
- PROBIO PROspection for BIOactive compounds in the North SeaFrom1 Nov 2019 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery and characterization of novel cannabinoid receptor ligands, type CB1 and/or CB2, for the treatment of neuropsychological disorders and neurodegenerative diseases.From19 Sep 2019 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity.From1 Jan 2019 → TodayFunding: FWO research project
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → TodayFunding: FWO research project
- The epigenetic effects of air pollutants on human Amniotic Fluid Stem Cells (hAFSCs)From1 Nov 2017 → 28 Jul 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery of new leads modulating voltage gated potassium ion channels as emerging cancer targetsFrom1 Oct 2017 → 30 Sep 2019Funding: BOF - Bilateral scientific cooperation
- Structure-based discovery of positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor as cognition enhancers.From1 Oct 2016 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Ionic Liquids as promising solvents for liquid-liquid microextractions in forensic toxicologyFrom25 Aug 2014 → 5 Jul 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- EAG1 as a target for cancer diagnosis and therapy in pediatric tumors: from early to late effects.From1 Jan 2014 → 27 Feb 2018Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 232 results
- Small cyclic sodium channel inhibitors(2021)
Authors: Steve Peigneur, Cristina da Costa Oliveira, Flavia Cristina de Sousa Fonseca, Kirsten L McMahon, Alexander Mueller, Olivier Cheneval, Ana Cristina Nogueira Freitas, Hana Starobova, Igor Dimitri Gama Duarte, David J Craik, et al.
Number of pages: 10 - Identification and Characterization of a Peptide from the Stony Coral Heliofungia actiniformis(2020)
Authors: Casey A Schmidt, David T Wilson, Ira Cooke, Jeremy Potriquet, Katie Tungatt, Visai Muruganandah, Chloe Boote, Felicity Kuek, John J Miles, Andreas Kupz, et al.
Pages: 3454 - 3463Number of pages: 10 - Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities(2020)
Authors: Irina Gladkikh, Steve Peigneur, Oksana Sintsova, Ernesto Lopes Pinheiro-Junior, Anna Klimovich, Alexander Menshov, Anatoly Kalinovsky, Marina Isaeva, Margarita Monastyrnaya, Emma Kozlovskaya, et al.
Number of pages: 17 - How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered.(2020)
Authors: Shunyi Zhu, Bin Gao, Steve Peigneur, Jan Tytgat
Pages: 3149 - 3164 - Pharmacological activity and NMR solution structure of the leech peptide HSTX-I(2020)
Authors: Kirsten L McMahon, Bryan Tay, Jennifer R Deuis, Brian S Tanaka, Steve Peigneur, Ai-Hua Jin, Jan Tytgat, Stephen G Waxman, Sulayman D Dib-Hajj, Irina Vetter, et al.
Number of pages: 10 - New insights in the mode of action of (+)-erythravine and (+)-11 alpha-hydroxy-erythravine alkaloids(2020)
Authors: Erica A Gelfuso, Suelen L Reis, Daiane SR Aguiar, Silmara A Faggion, Flavia MM Gomes, Diogo T Galan, Steve Peigneur, Ana MS Pereira, Marcia R Mortari, Alexandra OS Cunha, et al.
Number of pages: 7 - GiTx1(beta/kappa-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels(2020)
Authors: Gabriela Gontijo Montandon, Juliana Silva Cassoli, Steve Peigneur, Thiago Verano-Braga, Daniel Moreira dos Santos, Ana Luiza Bittencourt Paiva, Eder Ricardo de Moraes, Christopher Kushmerick, Marcia Helena Borges, Michael Richardson, et al.
Pages: 138 - 149Number of pages: 12 - Pioneering Study onRhopalurus crassicaudaScorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase(2020)
Authors: Caio B Abreu, Karla CF Bordon, Felipe A Cerni, Isadora S Oliveira, Carla Balenzuela, Gabriel M Alexandre-Silva, Karina F Zoccal, Mouzarllem B Reis, Gisele A Wiezel, Steve Peigneur, et al.
Number of pages: 15 - A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists(2020)
Authors: Steve Reynaud, Justyna Ciolek, Michel Degueldre, Natalie J Saez, Ana Filipa Sequeira, Yoan Duhoo, Joana LA Bras, Herve Meudal, Miguel Cabo Diez, Victoria Fernandez Pedrosa, et al.
Pages: 8250 - 8264Number of pages: 15 - Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report(2020)
Authors: Aleksandra Nijak, Alain J Labro, Hans De Wilde, Wendy Dewals, Steve Peigneur, Jan Tytgat, Dirk Snyders, Ewa Sieliwonczyk, Eline Simons, Emeline Van Craenenbroeck, et al.
Number of pages: 9