Structural studies of human small heat-shock protein HSPB1, its disease-related mutants and complexes with client proteins. KU Leuven
Small heat-shock proteins (sHSPs) are an important class of molecular chaperones found in all kingdoms of life. sHSPs bind partially unfolded proteins in an energy-independent fashion and prevent the formation of insoluble, toxic aggregates inside a cell. The human genome encodes ten different sHSPs the activities and mis-regulation of which are important for human health. In particular increased levels of one member, called HSPB1, has been ...