Projects
Exploration of the pharmacokinetics of clindamycin and its metabolites in special patients: from bioanalysis to clinical relevance KU Leuven
When antibiotics are administered to special patients like pregnant women as prophylactic drugs during fetal surgery, as well as during orthopedic and trauma surgery infections, the metabolism and pharmacokinetics are often different from reference patients without these specific characteristics. Furthermore, drug-drug interactions (DDIs) can also be relevant in the event of co-administration of drugs. The research of this dissertation will ...
In vitro and in silico investigation of pharmacokinetics in neonates undergoing therapeutic hypothermia KU Leuven
This PhD project ‘Understanding altered pharmacokinetics in neonates undergoing therapeutic hypothermia: integration of in vitro and in silico research' is a part of the FWO project 'I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling Therapy’. It is part of a collaboration between KU Leuven (Prof. Pieter Annaert, Prof. Karel Allegaert), UZ Leuven (Prof. Anne ...
Development and validation of a juvenile porcine model to study antibiotic tissue pharmacokinetics in pediatric sepsis. Ghent University
Performing pediatric drug research is extremely challenging. The development of animal models have been encouraged in guidance documents issued by the regulatory agencies. Pigs display a high degree of anatomical and physiological similarity to humans and are propagated as innovative juvenile animal model for reliable prediction of pediatric pharmacokinetic (PK) behavior. Previous research on antibiotic dose optimization in children is based ...
Use of fluorescent probes to study pharmacokinetics in zebrafish (Danio rerio) embryos and larvae KU Leuven
Despite the number of tools available for detecting toxicity in the drug discovery pipeline, post-marketing withdrawal due to toxic effects continues to be of an issue in the pharmaceutical industry. Many efforts have been made over the last years to improve the predictivity of in vitro and in vivo models that preclinically determine safety profiles of chemicals. Zebrafish (Danio rerio) offer new opportunities in this regard ...
Study on the influence of mycotoxin binders on the oral bioavailability, pharmacokinetics and tissue residues of veterinary drugs applied in poultry and pigs Ghent University
Recent EFSA guidelines (2010) state that in vivo efficacy and safety of the currently available mycotoxin binders need to be studied. This project aims to identify and test the most common mycotoxin binders for possible interactions with orally administered veterinary drugs. Therefore, appropriate in vitro and in vivo tests will be executed.
Mechanistic study on the prediction of the pharmacokinetics of drugs in children Ghent University
This project aims to evaluate the usefulness of Physiologically Based Pharmacokinetic (PBKP) - Modelling in predicting the pharmacokinetics of drugs en paediatric populations. Current knowledge on PBPK-modelling in children will be expanded, an the resulting model will be tested and validated using the model drugs tramadol and propofol.
A whole-body physiologically based pharmacokinetic model for personalized 161Tb-PRRT KU Leuven
Peptide receptor radionuclide therapy (PRRT) has been proven to be a safe and effective treatment of somatostatin receptor expressing neuroendocrine tumours (NETs). So far, standard activities are usually injected, although it has been shown that the variable tumour burden between patients can have a high impact on the biologically effective doses (BEDs) to normal tissues and tumour tissue with large tumour loads leading to a considerably ...
Investigation of bidirectional pharmacokinetic drug-drug interaction between vicagrel, a novel analogue for the antiplatelet drug clopidogrel, and atorvastatin KU Leuven
Research Aim 1)To investigate the risk and mechanisms of a possible bidirectional pharmacokinetic drug-drug interaction (DDI) between vicagrel, a potential replacement drug for the antiplatelet drug clopidogrel, and atorvastatin, a cardiovascular drug often used in clinical combination; 2)To develop a novel complex physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) model that can describe concentration-time profiles of ...