Organisations
Faculty of Bioscience Engineering Ghent University
Laboratory of Cell Death Research & Therapy (VIB-KUÂ Leuven) KU Leuven
The Laboratory of Cell Death Research & Therapy researches Defective regulation of cell death, especially in the form of apoptosis, contributes to the development of crucial pathologies including cancer and plays a major role in chemoresistance. Mechanisms regulating cancer cell death also affect the emission of ‘danger signals’ from the stressed/dying cells, which critically define their ‘immunogenic character’ and impact the initiation ...
Laboratory of Cellular Transport Systems KU Leuven
Research of the LabCTS team is focused on the molecular structure and function, the cell biological and (patho)physiological role of several members of the P-type ATPase family of transporters. These molecular machines generate vital ion or lipid transmembrane gradients across various biological membranes, driving many basic physiological processes. More specifically, our research concentrates on two classes of P-type ATPases.
One class ...
Laboratory of Lipid Metabolism and Cancer KU Leuven
The Laboratory of Lipid Metabolism and Cancer focusses on altered lipid metabolism in cancer cells. Using a state-of-the-art mass spectrometry-based lipidomics technology the group has made the intriguing observation that development and progression of cancer is almost invariably accompanied by dramatic changes in the cell’s composition of phospholipids. As phospholipids play a key role in the formation of membranes, which organize numerous ...
Laboratory of Membrane Trafficking (VIB-KUÂ Leuven) KU Leuven
The research in the Laboratory of Membrane Trafficking is focused on the cell biology and trafficking of the g-secretase components. This multiprotein complex has been implicated in a new signal transduction paradigm, called Regulated Intramembrane Proteolysis or RIP and is critical in a wide variety of important cellular activities including embryogenesis, brain development and haematopoiesis. RIP also plays a central role in Alzheimer's ...
Nephrology and Renal Transplantation Research Group KU Leuven
Patient-oriented research of factors impacting on the long term outcome of patients with chronic nephropathies both before and after starting renal replacement therapy. - Mechanisms underlying the inititiation and progression of glomerular diseases. * Evaluation of new methods to follow long term renal function in men. *Role of chronic hyperfiltration - effect of pharmacological interventions. * Role of persisting proteinuria. * Place of ...
Switch Laboratory (VIB-KUÂ Leuven) KU Leuven
Our research is focused on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular we are investigating how protein aggregation affects the cellular interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. The latter are especially relevant as they are usually associated to gain of function activities such as neurotoxicity ...