Nephrology and Renal Transplantation Research Group
Patient-oriented research of factors impacting on the long term outcome of patients with chronic nephropathies both before and after starting renal replacement therapy. - Mechanisms underlying the inititiation and progression of glomerular diseases. * Evaluation of new methods to follow long term renal function in men. *Role of chronic hyperfiltration - effect of pharmacological interventions. * Role of persisting proteinuria. * Place of immunosuppressive therapy in the progression of chronic glomerulonphritis. - Mechanisms underlying the occurence of accelerated atheromathosis in patients with chronic renal failure, patients in hemo- and peritoneal dialysis and recipients of a renal graft. Pharmacokinetic, pharmacodynamic and pharmacogenetic research of immunosuppressive drugs in transplantation. Ex-vivo cell based studies (PTEC) of nephrotoxicity of immunosuppressive drugs and mechanisms of chronic renal allograft fibrosis accordo,g to donor characteristics. Evaluation of non-invasive biomarkers of renal allograft status including fibrosis, drug toxicity and different types of acute and chronic allogrft rejection.- Study of the impact of new immunosuppressive agents on the early and late outcome of renal transplantation. - Study of the protective effect of vitamine D therapy on the occurrence of accelerated osteoporosis in renal transplant recipients. The role of uremic toxins and the relation with the microbiome and the bone-vascular axis. Biobank including tissue, blood and urine samples connected to clinical database. The role of apelin in the origin and progression of ADPKD. Nephrogenetics.