Projects
A study of the plasmodium vivax reticulocyte invasion pathways and ligan candidates, with special attention to the promising PvTRAg and PvRBP multigenic families. University of Antwerp
Allele-specific silencing of mutant KCNQ2 as a targeted treatment for KCNQ2 encephalopathy: an in vitro proof of concept study. University of Antwerp
Establishment and therapeutic targeting of disease signatures in patient-derived neuronal model of HINT1 neuropathy. University of Antwerp
Can we predict rate of cognitive decline in Alzheimer's disease based on genetic modifiers of differential gene expression in the default mode network? University of Antwerp
Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysis KU Leuven
Describing every single cell in the human body is one of the greatest challenges of our era. Single-cell technologies aim at mapping multiple properties of millions of single cells, both in health and disease. Flow cytometry is still the most important tool for single cell, targeted, protein-based analysis. However, standard fluorescence-based cytometry, which commonly measures <20 markers/cell, hampers major progress to map the enormous ...
Single-cell omics in high throughput and at spatial resolution KU Leuven
A human body comprises 10 to 100 billion cells (= 10 to 100 x 1000.000.000.000 cells). As most of our organ functions are executed by the concerted action of those individual cells in a spatially organised context, it is paramount to research individual cells in their native spatial context. This is not only important to understand normal organ development and function, but also to investigate how (subpopulations of) cells are perturbed in ...