The research in the Gynaecological Oncology laboratory covers 4 major fields:
Cancer and pregnancy. Our focus is on the continued long term follow up of children who were prenatally exposed to chemotherapy. In this framework, we are performing in vitrotransplacental studies. We also have a special interest in breast cancer during pregnancy. Research in both fields is performed in an international and interdisciplinary setting. Our group is spearheading the European task force "Cancer in Pregnancy".
Endometrial cancer, including uterine sarcomas.Our aim is to improve treatment by focusing on "targeted" treatment. In particular, the focus is on immunotherapy and the establishment of xenotransplants.
Ovarian and cervical cancer. We are intensively searching for new screening, prognostic and predictive markers (both genetic and proteomic) for these cancer types.
Pharmacogenetics of Breast cancer: Our aim is to identify SNPs that influence breast cancer response to treatment as well as uterine side effects in patients with an ER-positive tumor treated with tamoxifen. To study the pathogenesis of aromatase-related arthralgia we focus on the insulin-like growth hormone pathway, combining studies in an animal model with patient studies