Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 68
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO fellowships
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO fellowships
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Alternative RNA splicing as a predictor of response to checkpoint immunotherapyFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Exploring the reciprocal crosstalk between the vasculature in cancer to improve immunotherapyFrom15 Feb 2021 → TodayFunding: FWO fellowships, Foundations, funds and other with scientific goal
Publications
1 - 10 of 639
- The AI-2 dependent regulator LsrR has a limited regulon in Salmonella Typhimurium(2010)
Authors: Inge Thijs, Hui Zhao, Kristof Engelen, Jos Vanderleyden, Kathleen Marchal, Sigrid De Keersmaecker
Pages: 966 - 969 - Brominated furanones inhibit biofilm formation by Salmonella enterica serovar Typhimurium
Authors: Joost Janssens, Hans Steenackers, Stijn Robijns, Jeremy Levin, Hui Zhao, Kim Hermans, Kathleen Marchal, Jos Vanderleyden, Dirk De Vos, Sigrid De Keersmaecker
Pages: 6639 - 6648 - Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis(2019)
Authors: Diether Lambrechts, Patrick Neven, Ann Smeets, Hans Wildiers
Pages: 795 - 806 - Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?(2021)
Authors: Diether Lambrechts
- LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin β3 axis(2019)
Authors: Junbin Qian
Pages: 4851 - 4862 - Olmsted syndrome: exploration of the immunological phenotype(2013)
Authors: Dina Danso-Abeam, James Dooley, Lien Van Eyck, Esther Hauben, Marc Van De Velde, Chris Van Geet, Heidi Schaballie, Diether Lambrechts, Dean Franckaert, Stephanie Humblet-Baron, et al.
- Genetische profielscores en leeftijdsgerelateerde veranderingen in krachtparameters bij Vlaamse volwassenen na een tienjarie follow-up(2016)
Authors: Ruben Charlier, Sara Knaeps, Diether Lambrechts, Martine Thomis
Pages: 70 - 79 - A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (vol 12, 1078, 2021)(2021)
Authors: Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, et al.
- Common variants at 19p13 are associated with susceptibility to ovarian cancer (vol 42, pg 880, 2010)(2016)
Authors: Kelly L Bolton, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya-Yu Tsai, et al.
Pages: 101 - 101 - Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers(2016)
Authors: Dominique Schols, Christel Meuleman, Karen Peeraer, Carla Tomassetti, Xavier Bossuyt, Diether Lambrechts, Thomas D'Hooghe, Amelie Fassbender
Pages: 988 - 996