Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 31 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo Gonzalez Blas (Member)
- Kristofer Davie (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
Projects
1 - 10 of 57
- Applications of deep learning for cancer genomicsFrom20 Dec 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A whole-organism approach to uncover gene regulatory mechanisms in Drosophila melanogaster: towards a regulatory map at single-cell resolutionFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Evolution of gene regulatory networks in animal brainsFrom28 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Single-cell gene regulatory networks determining organoid developmentFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s diseaseFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping gene regulatory networks in the era of single-cell multi-omicsFrom1 Sep 2022 → TodayFunding: BOF - doctoral mandates
- Rebus EsperFrom29 Jun 2022 → TodayFunding: Other federal scientific institutions
- Advanced infrastructure for fabrication of next-generation micro- and nanosystemsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Cell-cell cOmmuNicaTion As a driver of Cancer cell state identiTy - Decoding the impact of cell-cell communications on the identity of tumor states in skin cancersFrom1 Jan 2022 → TodayFunding: FWO EOS
Publications
1 - 10 of 157
- First-in-Human Proof-of-Concept Study: Intralesional Administration of BQ788, an Endothelin Receptor B Antagonist, to Melanoma Skin Metastases(2015)
Authors: Jasper Wouters, Joost van den Oord
Pages: 1121 - 1122 - Cross-species analysis of enhancer logic using deep learning.(2020)
Authors: Liesbeth Minnoye, Ibrahim Ihsan Taskiran, David Mauduit, Maurizio Fazio, Linde Van Aerschot, Gert Hulselmans, Valerie Christiaens, Samira Makhzami, Monika Seltenhammer, Panagiotis Karras, et al.
Pages: 1815 - 1834 - Biallelic missense variants in ZBTB11 can cause intellectual disability in humans.(2018)
Authors: Ibrahim Ihsan Taskiran
Pages: 3177 - 3188 - TECHNOLOGICAL AND COMPUTATIONAL ADVANCEMENTS IN DROSOPHILA SINGLE-CELL OMICS(2021)
Authors: Kristofer Davie, Stein Aerts
- Epithelial-mesenchymal transition during invasion of cutaneous squamous cell carcinoma is paralleled by AKT activation(2014)
Authors: Kathleen Barrette, S Van Kelst, Jasper Wouters, Vivien Marasigan, Steffen Fieuws, Patrizia Agostinis, Joost van den Oord, Maria Garmyn
Pages: 1014 - 1021 - The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype(2020)
Authors: Jasper Wouters, David Nittner, Danny Huylebroeck, Joost van den Oord, Jean-Christophe Marine
Pages: 2983 - 2995 - Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks(2017)
Authors: Zeynep Kalender Atak, Hana Imrichova, Stein Aerts
Pages: 80 - Establishment of the mayfly Cloeon dipterum as a new model system to investigate insect evolution(2019)
Authors: Kristofer Davie, Stein Aerts
- Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye(2022)
Authors: Nikolai Hecker
- Computational methods to unravel perturbed transcriptional regulation in cancer(2019)
Authors: Bram Van de Sande, Stein Aerts