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Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 103
- Mutations in HspB1 and hereditary neuropathies(2020)
Authors: Sergei Strelkov
Pages: 655 - 665 - Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions(2020)
Authors: Giel Stalmans, Anastasia Lilina, Pieter-Jan Vermeire, Sergei Strelkov
- Effect of cataract-associated mutations in the N-terminal domain of αB-crystallin (HspB5)(2020)
Authors: Sergei Strelkov
- The Heterooligomerization of Human Small Heat Shock Proteins Is Controlled by Conserved Motif Located in the N-Terminal Domain(2020)
Authors: Sergei Strelkov
- Crystal structure of Arabidopsis thaliana neutral invertase 2(2020)
Authors: Evgenii Osipov, Wim Van den Ende, Sergei Strelkov
Pages: 152 - 157 - Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases(2020)
Authors: Luping Pang, Steff De Graef, Valentina Zorzini, Tassos Economou, Sergei Strelkov, Arthur Van Aerschot
Pages: 407 - 415 - Lateral A11 type tetramerization in lamins(2020)
Authors: Anastasia Lilina, Sergei Strelkov
- Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.(2019)
Authors: Machteld Sillen, Sergei Strelkov, Paul Declerck
Pages: 681 - 692 - Concatenation of 14-3-3 with partner phosphoproteins as a tool to study their interaction(2019)
Authors: Sergei Strelkov
- Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily(2019)
Authors: Dries De Ruysscher, Luping Pang, Steff De Graef, Manesh Nautiyal, Wim De Borggraeve, Jef Rozenski, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 252 - 264