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Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 103
- Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases(2019)
Authors: Manesh Nautiyal, Steff De Graef, Luping Pang, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 154 - 166 - Fragment-based drug design of antivirals targeting the polyomavirus capsid and flaviviral NS3-helicase(2018)
Authors: Ali Munawar, Sergei Strelkov
- Structure of intermediate filaments: progress and challenges(2018)
Authors: Sergei Strelkov
Pages: 508 - 508 - Discovery of Novel Druggable Sites on Zika Virus NS3 Helicase Using X-ray Crystallography-Based Fragment Screening(2018)
Authors: Ali Munawar, Eveline Lescrinier, Sergei Strelkov
Pages: 3664 - 3664 - Optimal data-driven parameterization of coiled coils(2018)
Authors: Sergei Strelkov
Pages: 125 - 129 - Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family(2018)
Authors: Oleg Klychnikov, Stephen Weeks, Sergei Strelkov
Pages: 11154 - 11165 - The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8(2018)
Authors: Stephen Weeks, Sergei Strelkov
- Family wide analysis of aminoacyl-sulfamoyl-3-deaza-adenosine analogues as inhibitors of aminoacyl-tRNA synthetases(2018)
Authors: Baole Zhang, Steff De Graef, Manesh Nautiyal, Luping Pang, Bharat Gadakh, Mathy Froeyen, Lieve Vanmellaert, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 384 - 396 - Characterization of human small heat shock protein HSPB1 alpha-crystallin domain localized mutants associated with hereditary motor neuron diseases(2018)
Authors: Stephen Weeks, Michelle Heirbaut, Sergei Strelkov
- Some properties of three αB-crystallin mutants carrying point substitutions in the C-terminal domain and associated with congenital diseases.(2017)
Authors: Evgeniia S Gerasimovich, Sergei Strelkov, Nikolai B Gusev
Pages: 168 - 178