Researcher
Paul Declerck
- Disciplines:Laboratory medicine, Regenerative medicine, Other basic sciences, Other health sciences, Other medical and health sciences, Medical biotechnology, Drug discovery and development, Pharmaceutics
Affiliations
- Therapeutic and Diagnostic Antibodies (Division)
Member
From1 Apr 2013 → 30 Sep 2023
Projects
1 - 10 of 28
- An integrated platform for the identification, isolation and characterization of human clock antibodies.From1 Jul 2021 → TodayFunding: Department Coordination
- VyCAP single cell isolation platform for high-quality single-cell analysisFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- A Pharmacometrics Approach to Improve Dose Individualisation Methods of Biologicals in Patients with Chronic Inflammatory DiseasesFrom13 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Development and streamlining a validation and implementation workflow for model-informed precision dosing for biologicals and antimicrobialsFrom1 Oct 2020 → 30 Sep 2022Funding: IOF - technology validation in lab
- Advancing DNA-based antibody therapeutics through evaluation and characterization of in vivo expression, complex antibody formats, and delivery formulationsFrom1 Sep 2020 → TodayFunding: FWO fellowships, Foundations, funds and other with scientific goal
- Anti-tau intrabodies for the treatment of Alzheimer’s diseaseFrom1 Feb 2020 → 19 Feb 2024Funding: Baekeland
- Extracellular Vesicle Tracking using surface proteins and Resonance Assays to detect breast Cancer in Early stage (EV-TRACE)From1 Jan 2020 → 31 Dec 2023Funding: FWO Strategic Basic Research (SBO)
- An on-chip single B cell mining platform for rapid development of fully human therapeutic antibodies and for immunoprofiling human antibody responsesFrom1 Oct 2019 → 30 Sep 2022Funding: IOF - technology validation in lab
- Development and validation of sampling and rapid assay methods for vedozilumab and ustekinumab therapeutic drug monitoringFrom1 Dec 2018 → 30 Nov 2020Funding: Foreign private sponsor - undefined
- BIOLOPTIM: implementing therapeutic drug monitoring of biologics for psoriasis and hidradenitis suppurativaFrom1 Oct 2018 → TodayFunding: FWO Applied Biomedical Research (TBM)
Publications
1 - 10 of 197
- Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies(2023)
Authors: Paul Declerck
- DEVELOPMENT OF ANTI-TAU INTRABODIES TO TARGET TAU PATHOLOGY IN ALZHEIMER’S DISEASE(2023)
Authors: Dina Rodrigues Martins, Paul Declerck
- FLUIDOT: A case study on drug tolerance screening and antibody mining, one cell at a time(2023)
Authors: Karen Ven, Jolien Breukers, Iene Rutten, Maya Imbrechts, Sam Noppen, Dominique Schols, Paul De Munter, Hendrik Jan Thibaut, Karen Vanhoorelbeke, Dragana Spasic, et al.
- Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice(2023)
Authors: Marie-Lynn Cuypers, Nick Geukens, Paul Declerck, Maarten Dewilde
- Higher Drug Exposure During the First 24 Weeks of Ustekinumab Treatment Is Associated With Endoscopic Remission in Crohn's Disease(2023)
Authors: Bram Verstockt, Séverine Vermeire, Debby Thomas, Paul Declerck
Pages: 838 - + - FLUIDOT: a Modular Microfluidic Platform for Single-Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining(2023)
Authors: Jolien Breukers, Karen Ven, Iene Rutten, Maya Imbrechts, Julie Van Lent, Winnie Kerstens, Sam Noppen, Dominique Schols, Hendrik Jan Thibaut, Karen Vanhoorelbeke, et al.
- Evaluation of serum cytokines and acute phase proteins as possible pharmacodynamic biomarkers to monitor endoscopic remission during ustekinumab therapy in patients with Crohn's disease(2023)
Authors: Nathalie Van den Berghe, Dahham Alsoud, Bram Verstockt, Séverine Vermeire, Paul Declerck, Debby Thomas
- Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model(2022)
Authors: Debby Thomas, Maarten Dewilde, Nick Geukens, Paul Declerck
- Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model(2022)
Authors: Maya Imbrechts, Wim Maes, Louanne Ampofo, Nathalie Van den Berghe, Bas Calcoen, Winnie Kerstens, Madina Rasulova, Sam Noppen, Rana Abdelnabi, Piet Maes, et al.
- Biosimilar Use and Switching in Belgium: Avenues for Integrated Policymaking(2022)
Authors: Liese Barbier, Steven Simoens, Paul Declerck, Arnold Vulto, Isabelle Huys
Patents
1 - 1 of 1
- Dual targeting of tafi and pai-1 (Inventor)
Linked dataset
1 - 1 of 1