Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 103
- Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies(2021)
Authors: Luping Pang, Sergei Strelkov, Arthur Van Aerschot
- Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors(2021)
Authors: Dries De Ruysscher, Luping Pang, Stijn Lenders, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484(2021)
Authors: Machteld Sillen, Sergei Strelkov, Paul Declerck
- Structural analysis of antibody-based and small molecule profibrinolytics(2021)
Authors: Machteld Sillen, Paul Declerck, Sergei Strelkov
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors(2020)
Authors: Luping Pang, Steff De Graef, Eveline Lescrinier, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies(2020)
Authors: Luping Pang, Arthur Van Aerschot, Sergei Strelkov, Stephen Weeks
- Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase(2020)
Authors: Luping Pang, Steff De Graef, Sergei Strelkov, Arthur Van Aerschot
- Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity(2020)
Authors: Machteld Sillen, Sergei Strelkov, Paul Declerck
- Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase(2020)
Authors: Dries De Ruysscher, Luping Pang, Charles-Alexandre Mattelaer, Steff De Graef, Jef Rozenski, Sergei Strelkov, Eveline Lescrinier, Arthur Van Aerschot
- Structural studies of aminoacyl-tRNA synthetases: development of new antibiotics(2020)
Authors: Steff De Graef, Sergei Strelkov, Arthur Van Aerschot, Stephen Weeks