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Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
41 - 50 of 103
- CCFold: rapid and accurate prediction of coiled-coil structures and application to modeling intermediate filaments(2017)
Authors: Dmytro Guzenko, Sergei Strelkov
Pages: 215 - 222 - Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1(2017)
Authors: Michelle Heirbaut, Sergei Strelkov, Stephen Weeks
Pages: 9944 - 9957 - N-terminal half of transportin SR2 interacts with HIV integrase(2017)
Authors: Jolien Blokken, Flore De Wit, Stéphanie De Houwer, Zeger Debyser, Frauke Christ, Sergei Strelkov
Pages: 9699 - 9710 - Granular clustering of de novo protein models(2017)
Authors: Dmytro Guzenko, Sergei Strelkov
Pages: 390 - 396 - Structural basis for the interaction of a human small heat shock protein with the 14-3-3 universal signaling regulator(2017)
Authors: Stephen Weeks, Sergei Strelkov
Pages: 305 - 316 - Crystallographic Studies of Intermediate Filament Proteins(2017)
Authors: Dmytro Guzenko, Sergei Strelkov
Pages: 151 - 170 - Some properties of three alpha B-crystallin mutants carrying point substitutions in the C-terminal domain and associated with congenital diseases(2017)
Authors: Sergei Strelkov
Pages: 168 - 178 - The growing world of small heat shock proteins: from structure to functions(2017)
Authors: Sergei Strelkov
Pages: 601 - 611 - The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain(2016)
Authors: Michelle Heirbaut, Sergei Strelkov, Stephen Weeks
Pages: 41 - 50 - Elucidation of the molecular mechanisms of two nanobodies that inhibit TAFI activation and TAFIa activity(2016)
Authors: Xiaohua ZHOU, Stephen Weeks, Sergei Strelkov, Paul Declerck
Pages: 1629 - 1638