Researcher
Mohamed Lamkanfi
- Keywords:Cell death and inflammation
- Disciplines:Immunology not elsewhere classified, Cell signalling, Applied immunology, Innate immunity, Autoimmunity, Immunogenetics
Affiliations
- Department of Internal Medicine and Pediatrics (Department)
Member
From1 Oct 2018 → Today - Department of Internal medicine (Department)
Member
From1 Oct 2015 → 30 Sep 2018 - Department of Biochemistry (Department)
Member
From5 Aug 2009 → 30 Sep 2015 - Research Department (Administrative office)
Member
From1 Jul 2005 → 30 Jun 2006 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 2000 → 30 Sep 2004
Projects
1 - 10 of 28
- Novel mechanisms of inflammation and cell death regulation in autoinflammatory and infectious diseasesFrom1 Jan 2023 → TodayFunding: BOF - projects
- HIGH-THROUGHPUT, HIGH-SENSITIVITY AND COST-EFFECTIVE MONITORING OF INNATE AND ADAPTIVE IMMUNE RESPONSES AT SINGLE CELL LEVELFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- A MESO QuickPlex SQ system to measure single or multiple immunotargets in biofluidsFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Targeting NLRP3-mediated inflammation with novel chemotypesFrom1 Oct 2022 → 31 Mar 2024Funding: Horizon Europe - European Research Council (ERC)
- Cell Death Regulation and Role in Infection and Inflammatory DiseasesFrom1 Jan 2022 → TodayFunding: FWO EOS
- Single cell analysis of inflammasome-mediated IL-1ß secretion in primary human monocytesFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting the Tumor Microenvironment in Colorectal Peritoneal MetastasesFrom1 Jan 2021 → TodayFunding: BOF - projects
- Regulation of the Nlrp1a inflammasome in cutaneous and systemic autoinflammationFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Mechanisms and regulation of inflammasome-associated programmed cell deathFrom1 Jan 2020 → 31 Dec 2021Funding: H2020 - Frontier Research (ERC)
- Investigating microglia inflammasome activation and regulation in
Alzheimer diseaseFrom1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research Grant
Publications
31 - 40 of 131
- A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation(2019)
Authors: Simon Tavernier, V Athanasopoulos, PATRICK VERLOO, G Behrens, Jens Staal, Delfien Bogaert, Leslie Naesens, Marieke De Bruyne, Sofie Van Gassen, Eef Parthoens, et al.
- MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition(2019)
Authors: Lieselotte Vande Walle, Irma B Stowe, Pavel Sacha, Bettina L Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro Henrique Viana Saavedra, Petr Simon, Vladimir Subrt, et al.
- Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis(2019)
Authors: Melanie Fritsch, Saskia D Gunther, Robin Schwarzer, Marie-Christine Albert, Fabian Schorn, J Paul Werthenbach, Lars M Schiffmann, Neil Stair, Hannah Stocks, Jens M Seeger, et al.
Pages: 683 - 687 - DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages(2019)
Authors: Nathalia Moraes de Vasconcelos, Gwendolyn Vliegen, Amanda Gonçalves, Emilie De Hert, Rosa Martín-Pérez, Nina Van Opdenbosch, Anvesh Jallapally, Ruth Geiss-Friedlander, Anne-Marie Lambeir, Koen Augustyns, et al.
- Inflammasomes in neuroinflammatory and neurodegenerative diseases(2019)
Authors: Sofie Voet, Sahana Srinivasan, Mohamed Lamkanfi, Geert van Loo
- Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax(2019)
Authors: Antonella Fioravanti, Filip Van Hauwermeiren, Sander E Van der Verren, Wim Jonckheere, Amanda Gonçalves, Els Pardon, Jan Steyaert, Henri De Greve, Mohamed Lamkanfi, Han Remaut
Pages: 1805 - 1814 - Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection(2019)
Authors: Hanne Dubois, Frederic Sorgeloos, Soroush T. Sarvestani, Liesbet Martens, Yvan Saeys, Jason M. Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert
- Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis(2018)
Authors: Pedro Henrique Viana Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
- GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever(2018)
Authors: Apurva Kanneganti, RK Subbarao Malireddi, Pedro Henrique Viana Saavedra, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R Luo, Ramnik J Xavier, Hongbo Chi, et al.
Pages: 1519 - 1529 - Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally innplanted foreign bodies(2018)
Authors: Ona Rogiers, Michelle Holtappels, Wafi Siala, Mohamed Lamkanfi, Francoise Van Bambeke, Katrien Lagrou, Patrick Van Dijck, Sona Kucharikova
Pages: 2806 - 2814
Patents
1 - 1 of 1
- Label free detection of protease activity (Inventor)