Researcher
Ludo Van Den Bosch
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Responsible
From1 Oct 2018 → Today - Van Den Bosch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today - Research Group Experimental Neurology (Division)
Member
From1 Oct 2002 → 31 Dec 2011
Projects
1 - 10 of 60
- Investigating the pathological mechanisms underlying KIF5A mutations in ALSFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Engineering Functional 3D Neuromuscular Junctions: Investigating Myogenic Stem Cell Differentiation and Integration with iPSC-Derived Motor NeuronsFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating fatty acid toxicity in amyotrophic lateral sclerosisFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Investigating the therapeutic potential of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS) using human induced pluripotent stem cells (iPSCs).From1 May 2023 → TodayFunding: Other federal public and semi-governmental institutions
- FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanismsFrom19 Apr 2023 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- Creating iPSC-derived 3D human neuromuscular junctions to investigate amyotrophic lateral sclerosis (ALS)From15 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating mechanisms of RNA misprocessing in Amyotrophic Lateral SclerosisFrom8 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Determination and investigation of the therapeutic targets of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS)From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Creation of a humanized mouse model for demyelinating peripheral neuropathies as a platform for therapeutic testing.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Investigating the role of DNA damage and repair in the selective motor neuron death during amyotrophic lateral sclerosis (ALS)From15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 231
- FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and mechanisms(2023)
Authors: Lisanne Terrie, Pegah Masrori, Philip Van Damme, Lieven Thorrez, Ludo Van Den Bosch
- F/YGG-motif is an intrinsically disordered nucleic-acid binding motif(2022)
Authors: Joris Van Lindt, Ludo Van Den Bosch
Pages: 622 - 635 - Unravelling the mechanisms of motor neuron degeneration in relation to TDP-43 pathology in amyotrophic lateral sclerosis(2022)
Authors: Evelien Van Schoor, Dietmar Thal, Ludo Van Den Bosch, Philip Van Damme
- Chemical Tools to Investigate Neurological Diseases(2022)
Authors: Yvonne Klingl, Ludo Van Den Bosch
- Utilising CRISPR-Cas13 systems to target frontotemporal dementia and amyotrophic lateral sclerosis-causing C9orf72 repeat expansion-containing RNA(2022)
Authors: Ludo Van Den Bosch
Pages: A8 - A9 - Hexanucleotide repeat RNA-binding proteins as modifiers of RNA toxicity in C9orf72 ALS/FTD(2022)
Authors: Elke Braems, Ludo Van Den Bosch, Valérie Bercier, Bart Swinnen
- Modeling Amyotrophic Lateral Sclerosis: Human iPSC-derived Astrocytes and Neuromuscular Junctions in Microfluidic Devices(2022)
Authors: Katarina Dittlau, Ludo Van Den Bosch
- HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS(2022)
Authors: Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers, Ilse Geudens, Dietmar Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch
Pages: 465 - 488 - Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex(2022)
Authors: Evelien Van Schoor, Sandra Oliveira Tomé, Philip Van Damme, Ludo Van Den Bosch, Dietmar Thal
Pages: 393 - 411 - Modeling CMT1A and investigating HDAC inhibitors as a therapeutic strategy(2022)
Authors: Robert Ciarán Prior, Ludo Van Den Bosch
Patents
1 - 4 of 4