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Researcher
Ludo Van Den Bosch
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Responsible
From1 Oct 2018 → Today - Van Den Bosch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today - Research Group Experimental Neurology (Division)
Member
From1 Oct 2002 → 31 Dec 2011
Projects
31 - 40 of 60
- Intracellular dynamics of disease-associated proteins in amyotrophic lateral sclerosis (ALS)From1 Oct 2017 → 30 Sep 2022Funding: Fund Recuperation Fiscal Exemption
- Elucidating the role of mutated fuced in sacroma (FUS) oligodenrocytes in the pathophysiology of amyotrophic lateral sclerosis using induced pluripotent stem cells.From1 Sep 2017 → 31 Dec 2021Funding: FWO fellowships
- Drosophila melanogaster as a screening model to find new therapeutic targets in ALSFrom1 Jan 2017 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Role of nucleocytoplasmic transport in amyotrophic lateral scleroris (ALS)From1 Oct 2016 → 25 Mar 2021Funding: FWO fellowships
- Axonal transport defects in C9orf72 ALS/FTD: the role of dipeptide repeat proteinsFrom8 Jan 2016 → 21 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- iPSC: Therapeutic target identification for FTD/ALS using human induced pluripotent stem cell modelsFrom1 Nov 2015 → 31 Oct 2019Funding: SBO (Strategic basic research)
- Investigation of axonal transport deficits in Charcot-Marie-Tooth disease type 1A and modification through selective inhibition of histone deacetylase 6From20 Oct 2015 → 6 Jul 2022Funding: FWO Strategic Basic Research Grant
- Unraveling the psychological and pathophysiological role of the interaction between the N-terminal complexity domain and the C-terminus of FUS.From1 Jan 2015 → 31 Dec 2016Funding: Foundations, funds and other with scientific goal
- Small heat-shock proteins in health and disease.From1 Jan 2015 → 31 Dec 2021Funding: FWO scientific research network
- Mechanism and treatment of chemotherapy-induced peripheral neuropathiesFrom1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 231
- FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.(2024)
Authors: Ludo Van Den Bosch
Pages: 2156 - The sense of antisense therapies in ALS.(2024)
Authors: Philip Van Damme, Ludo Van Den Bosch
Pages: 252 - 262 - TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish(2024)
Authors: Philip Van Damme, Dietmar Thal, Valérie Bercier, Ludo Van Den Bosch
- Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies.(2024)
Authors: Ludo Van Den Bosch
Pages: e4936 - PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport.(2024)
Authors: Thibaut Burg, Philip Van Damme, Ludo Van Den Bosch
Pages: 41 - Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit(2023)
Authors: Ludo Van Den Bosch
Pages: 1821 - 1843 - Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma(2023)
Authors: Lise Finotto, Basiel Cole, Maxime Vanmechelen, Bram Boeckx, Diether Lambrechts, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet
- Proteostasis plays an important role in demyelinating Charcot Marie Tooth disease.(2023)
Authors: Ludo Van Den Bosch
Pages: 115760 - lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons(2023)
Authors: Ludo Van Den Bosch
- TDP‑43 pathology is associated with increased tau burdens and seeding(2023)
Authors: Sandra Oliveira Tomé, Grigoria Tsaka, Klara Gawor, Philip Van Damme, Ludo Van Den Bosch, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Thal
Patents
1 - 4 of 4